Evidence map›Paper›PMID 35299958›Full record

ArticleFrontiers in endocrinology2022

Peptide Model of the Mutant Proinsulin Syndrome. II. Nascent Structure and Biological Implications.

Yanwu Yang, Michael D Glidden, Balamurugan Dhayalan, Alexander N Zaykov, Yen-Shan Chen, Nalinda P Wickramasinghe, Richard D DiMarchi, Michael A Weiss

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Yanwu YangDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, United States.
Michael D GliddenDepartment of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
Balamurugan DhayalanDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, United States.
Alexander N ZaykovDepartment of Chemistry, Indiana University, Bloomington, IN, United States.
Yen-Shan ChenDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, United States.
Nalinda P WickramasingheDepartment of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
Richard D DiMarchiDepartment of Chemistry, Indiana University, Bloomington, IN, United States.
Michael A WeissDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, United States.
Indiana University Bloomington · USIndiana University – Purdue University Indianapolis · USIndiana University School of MedicineCase Western Reserve University · USUniversity School · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
Non-Standard Protein Design in Molecular Endocrinology: Insulin and GlucagonR01DK040949 · NIDDK · UNIVERSITY OF CHICAGO · PI CHERRINGTON, ALAN D, GEORGIADIS, MILLIE M · 1989 to 2024
$8.4M
How mutations in proinsulin cause diabetes: a protein-misfolding diseaseR01DK069764 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI ARVAN, PETER, KENT, STEPHEN B.H. · 2004 to 2014
$3.5M
Studies of an ultra-stable single-chain insulin and its therapeutic implicationsF30DK104618 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI GLIDDEN, MICHAEL · 2015 to 2018
$191k
NIDDK NIH HHS F30 DK104618NIDDK NIH HHS R01 DK040949NIGMS NIH HHS T32 GM007250
6 · The paper itself

Abstract

Toxic misfolding of proinsulin variants in β-cells defines a monogenic diabetes syndrome, designated

Indexed as

Diabetes MellitusProinsulinAdolescentDisulfidesHumansInfant, NewbornInsulinProtein FoldingDisulfidesInsulinProinsulinfolding nucleusmonogenic diabetesNMR spectroscopyoxidative folding intermediatepeptide chemistryprotein folding

Identifiers

PMID35299958
PMCPMC8922542
OpenAlexW4214485396

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.