ReviewInfection and drug resistance2022
Early-Onset Neonatal Sepsis in Low- and Middle-Income Countries: Current Challenges and Future Opportunities.
Review in Infection and drug resistance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Neonatal Colonization With Antibiotic-Resistant Pathogens in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Shorter versus longer duration antibiotic regimens for treatment of suspected neonatal sepsis.The Cochrane database of systematic reviews · 2024Pooled it
- Prevalence and factors associated with maternal and neonatal sepsis in sub-Saharan Africa: a systematic review and meta-analysis.Frontiers in public health · 2024Pooled it
- Impact of Intrapartum Azithromycin on the Carriage and Antibiotic Resistance of Escherichia coli and Klebsiella pneumoniae in Mothers and Their Newborns: A Substudy of a Randomized, Double-Blind Trial Conducted in The Gambia and Burkina Faso.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Trial
- Cohort profile: Infant Gut Bacterial Study in Pakistan (INBUGS-P) longitudinal birth cohort.BMJ open · 2026Article
- Neonatal Bloodstream Infections: A Narrative Review on Diagnostic and Therapeutic Challenges and Prospects in Developing Countries.Health science reports · 2026Article
- Antimicrobial Stewardship Program in a Low-Middle Income Country: Impact of an Antibiotic Guideline for Neonatal Early-Onset Sepsis.Antibiotics (Basel, Switzerland) · 2026Article
- Observational
- Maternal and neonatal determinants of newborn sepsis: A case-control study in resource-limited settings.World journal of clinical pediatrics · 2026Article
- "Overview of Global Challenges in Dealing with Neonatal Sepsis and Responsibility of Healthcare Workers": A Narrative Review.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2026Review
- Combination of aztreonam, colistin and tigecycline in the treatment of neonatal carbapenemase-producing Enterobacteriaceae infection: a case report.BMC pediatrics · 2026Article
- Development and Validation of a Diagnostic Prediction Model for Neonatal Sepsis in a Low-Resource Setting, Ethiopia.Journal of epidemiology and global health · 2025Article
- Contribution of maternal gut carriage to neonatal acquisition of extended-spectrum beta-lactamase-producing Enterobacterales in Madagascar and Cambodia.Nature communications · 2025Article
- Is Shorter (3-4 Days) Antibiotic Therapy Adequate Compared to Standard (5-7 Days) Duration in Neonates with Suspected (Culture Negative) Sepsis? No.Indian pediatrics · 2025Article
- Epidemiology of early-onset neonatal sepsis in Qatar, 2015-2022: a multicentre retrospective cohort study.BMJ paediatrics open · 2025Article
- Development of a Bloodstream Infection Surveillance Programme at a Resource-Limited South African Neonatal Unit.Antibiotics (Basel, Switzerland) · 2025Article
- Time to recovery of neonatal sepsis and its predictors in public hospitals of North Shoa Zone, Central Ethiopia.BMC infectious diseases · 2025Article
- Antibiotic Prescription Practice and Resistance Patterns of Bacterial Isolates from a Neonatal Intensive Care Unit: A Retrospective Study from Jordan.Antibiotics (Basel, Switzerland) · 2025Article
- Prevalence and factors associated with neonatal sepsis in Mali: a cross-sectional study.BMJ open · 2025Article
- Insights of SEDRIC, the Surveillance and Epidemiology of Drug-Resistant Infections Consortium.Wellcome open research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neonatal sepsis is defined as a systemic infection within the first 28 days of life, with early-onset sepsis (EOS) occurring within the first 72h, although the definition of EOS varies in literature. Whilst the global incidence has dramatically reduced over the last decade, neonatal sepsis remains an important cause of neonatal mortality, highest in low- and middle-income countries (LMICs). Symptoms at the onset of neonatal sepsis can be subtle, and therefore EOS is often difficult to diagnose from clinical presentation and laboratory testing and blood cultures are not always conclusive or accessible, especially in resource limited countries. Although the World Health Organisation (WHO) currently advocates a ß-lactam, and gentamicin for first line treatment, availability and cost influence the empirical antibiotic therapy administered. Antibiotic treatment of neonatal sepsis in LMICs is highly variable, partially caused by factors such as cost of antibiotics (and who pays for them) and access to certain antibiotics. Antimicrobial resistance (AMR) has increased considerably over the past decade and this review discusses current microbiology data available in the context of the diagnosis, and treatment for EOS. Importantly, this review highlights a large variability in data availability, methodology, availability of diagnostics, and aetiology of sepsis pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.