Evidence map›Paper›PMID 35299680›Full record

ArticleJournal of healthcare engineering2022

Synergistic Effect of Stereotactic Radiotherapy Combined with Karelizumab on Patients with Advanced NSCLC.

Jiayou Guo, Jiayi Guo, Beibei Cheng, Xingbang Sun, Hongwei Zhang, Jianxin Ma

RetractedAbstract readRetracted Publication
In one paragraph

Article in Journal of healthcare engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jiayou GuoDepartment of Oncology, Lianyungang Oriental Hospital Affiliated to Xuzhou Medical University, Lianyun 222042, China.
Jiayi GuoDepartment of Oncology, Lianyungang Oriental Hospital Affiliated to Xuzhou Medical University, Lianyun 222042, China.
Beibei ChengDepartment of Oncology, Lianyungang Oriental Hospital Affiliated to Xuzhou Medical University, Lianyun 222042, China.
Xingbang SunDepartment of Oncology, Lianyungang Oriental Hospital Affiliated to Xuzhou Medical University, Lianyun 222042, China.
Hongwei ZhangDepartment of Oncology, Lianyungang Oriental Hospital Affiliated to Xuzhou Medical University, Lianyun 222042, China.
Jianxin MaDepartment of Oncology, Lianyungang Oriental Hospital Affiliated to Xuzhou Medical University, Lianyun 222042, China.ORCID 0000-0003-0113-5954

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this paper, synergistic effects of stereotactic radiotherapy (SRS) combined with karelizumab on the patients with advanced NSCLC have been analyzed through extensive experiments. For this purpose, 100 patients with advanced NSCLC in our hospital from December 2018 to December 2020 were selected and divided into control group and observation group. The control group was treated with SRS, while the observation group was treated with karelizumab at the same time. The data of age, gender, BMI, pathological type, and clinical stage were collected and recorded. After 3 months of treatment, the short-term efficacy of the two groups was evaluated according to RECIST solid tumor efficacy evaluation standard. Fasting venous blood of all patients before and 3 months after treatment was collected. The serum levels of matrix metalloproteinase-9 (MMP-9), cytokeratin 19 fragment (CY211), carcinoembryonic antigen (CEA), and vascular endothelial growth factor (VEGF) were detected by the enzyme-linked immunosorbent assay. The KPS score was used to evaluate the quality of life before and after treatment. The incidence of fatigue, diarrhea, and other adverse reactions were compared between the two groups. The patients were followed up for 3 years, and the survival of all patients was recorded. The total effective rate of the observation group was 50.00% (23/46), which was evidently higher than that (27.78% (15/54)) of the control group (

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsCarcinoembryonic AntigenHumansMatrix Metalloproteinase 9Quality of LifeVascular Endothelial Growth Factor ACarcinoembryonic AntigenMatrix Metalloproteinase 9Vascular Endothelial Growth Factor A

Identifiers

PMID35299680
PMCPMC8923784

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.