Evidence map›Paper›PMID 35299622›Full record

ArticleFrontiers in neuroscience2022

Mendelian Randomization Analysis Suggests No Associations of Herpes Simplex Virus Infections With Multiple Sclerosis.

Wan Zhang, Pengfei Wu, Rui Yin, Meichen Sun, Rongsen Zhang, Xiaoyao Liao, Yuhong Lin, Hui Lu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 3 countries.

Wan ZhangDepartment of Biology, Boston University, Boston, MA, United States.
Pengfei WuDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Rui YinDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, United States.
Meichen SunDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Rongsen ZhangDepartment of Ultrasound, Second Xiangya Hospital, Central South University, Changsha, China.
Xiaoyao LiaoCollege of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Yuhong LinZhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Hui LuDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Capital Medical University · CNBoston University · USCentral South University · CNHarvard University · USSecond Xiangya Hospital of Central South University · CNSun Yat-sen University · CNUniversity of Glasgow · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies have suggested an association between infection with herpes simplex virus (HSV) and liability to multiple sclerosis (MS), but it remains largely unknown whether the effect is causal. We performed a two-sample Mendelian randomization (MR) study to explore the relationship between genetically predicted HSV infection and MS risk. Genetic instrumental variables for diagnosed infections with HSV (

Indexed as

causal risk factorsgenetic epidemiologyherpes simplex virusMendelian randomizationmultiple sclerosis

Identifiers

PMID35299622
PMCPMC8920987
OpenAlexW4214511247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.