ArticlePloS one2022
Derivation and validation of the Rapid Assessment of Dementia Risk (RADaR) for older adults.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Discriminative performance of externally validated dementia risk prediction models: a systematic review and meta-analysis.BMC medicine · 2026Pooled it
- A critical review and classification of dementia risk assessment tools to inform dementia risk reduction.The journal of prevention of Alzheimer's disease · 2025Pooled it
- Mild cognitive impairment cases affect the predictive power of Alzheimer's disease diagnostic models using routine clinical variables.npj aging · 2026Article
- Assessing Cognitive Decline and Dementia Risk in Black and White Older Adults With Blood Biomarkers pTau217, GFAP, NfL, and Aβ Ratio.Neurology · 2025Article
- Developing multifactorial dementia prediction models using clinical variables from cohorts in the US and Australia.Translational psychiatry · 2025Article
- External validation of dementia prediction models in Black or African American and White older adults: A longitudinal population-based study in the United States.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Dementia and comorbidities in primary care: a scoping review.BMC primary care · 2023Article
- Dementia Risk Models in an Australian First Nations Population: Cross-Sectional Associations and Preparation for Follow-Up.Journal of Alzheimer's disease reports · 2023Article
- Validation of the CogDrisk Instrument as Predictive of Dementia in Four General Community-Dwelling Populations.The journal of prevention of Alzheimer's disease · 2023Article
- Observational
- An Intelligent Learning System for Unbiased Prediction of Dementia Based on Autoencoder and Adaboost Ensemble Learning.Life (Basel, Switzerland) · 2022Article
- Improving Early Detection of Cognitive Impairment in Older Adults in Primary Care Clinics: Recommendations From an Interdisciplinary Geriatrics Summit.Annals of family medicineArticle
- What's New in Dementia Risk Prediction Modelling? An Updated Systematic Review.Dementia and geriatric cognitive disorders extraReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThere is no practical dementia risk score in the clinical setting.
objectiveTo derive and validate a score obtained by a rapid and simple assessment, which guides primary care providers in predicting the risk of dementia among older adults.
designA total of 4178 participants from three longitudinal cohorts (mean age at baseline = 76.8 [SD = 7.6] years), without baseline dementia, followed annually for a median of 10 years (IQR: 5 to16 years, Reverse Kaplan-Meier).
participantsTo derive the score, we used data from 1,780 participants from the Rush Memory and Aging Project (93% White). To validate the score, we used data from 1,299 participants from the Religious Order Study (92% White), and to assess generalizability, 679 participants from the Minority Aging Research Study (100% Black). MEASUREMENTS: Clinician-based dementia diagnosis at any time after baseline and predictive variables associated with dementia risk that can be collected in a primary care setting: demographics, clinical indicators, medical history, memory complaints, cognitive and motor tests, and questions to assess functional disability, depressive symptoms, sleep, social isolation, and genetics (APOE e4 and AD polygenic risk score).
resultsAt baseline, age, memory complaint, the ability to handle finances, the recall of the month, recall of the room, and recall of three words, were associated with the cumulative incidence of dementia, in the derivation cohort. The discrimination of the RADaR (Rapid Risk Assessment of Dementia) was good for the derivation and external-validation cohorts (AUC3 years = 0.82-0.86), compared to the overall discrimination of age alone (AUC3 years = 0.73), a major risk factor for dementia. Adding genetic data did not increase discrimination. LIMITATIONS: Participants were volunteers, may not represent the general population.
conclusionsThe RADaR, derived from community-dwelling older persons, is a brief and valid tool to predict dementia risk at 3 years in older White and Black persons.
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