Evidence map›Paper›PMID 35298916›Full record

ArticleNeuron2022

Interneurons direct circuit-specific flow of information to communicate stressful experiences.

Kirstie Cummings, Jamie Maguire

Abstract readComment
PubMed Publisher
In one paragraph

Article in Neuron, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Kirstie CummingsDepartment of Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, 1825 University Blvd., Birmingham, AL 35233, USA.
Jamie MaguireNeuroscience Department, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111, USA. Electronic address: jamie.maguire@tufts.edu.

Funding

Neuroactive steroids as novel psychiatric treatments: mechanistic studiesP50MH122379 · NIMH · WASHINGTON UNIVERSITY · PI COVEY, DOUGLAS F · 2021 to 2025
$12.2M
Investigating the pathological consequences of seizure-induced activation of the HPA axisR01NS102937 · NINDS · TUFTS UNIVERSITY BOSTON · PI Jamie Lynn Maguire · 2017 to 2026
$4.2M
Stress-induced impairments in endogenous neurosteroid signaling in the BLA negatively impacts network and behavioral statesR01MH128235 · NIMH · TUFTS UNIVERSITY BOSTON · PI MAGUIRE, JAMIE LYNN · 2021 to 2025
$2.5M
Interneurons tune the neural circuits mediating the anxiolytic effects of alcoholR01AA026256 · NIAAA · TUFTS UNIVERSITY BOSTON · PI MAGUIRE, JAMIE LYNN · 2018 to 2022
$1.9M
Disruption in the network communication of safety in epilepsy with comorbid anxietyR01NS105628 · NINDS · TUFTS UNIVERSITY BOSTON · PI MAGUIRE, JAMIE LYNN · 2019 to 2022
$1.6M
Ventromedial Prefrontal Cortex Regulation of Fear MemoryR00MH122228 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUMMINGS, KIRSTIE ALYSSA · 2022 to 2024
$722k
Endogenous neurosteroids constrain network activity and limit seizure susceptibilityR21NS120868 · NINDS · TUFTS UNIVERSITY BOSTON · PI MAGUIRE, JAMIE LYNN · 2021 to 2021
$454k
NIAAA NIH HHS R01 AA026256NIMH NIH HHS P50 MH122379NIMH NIH HHS R00 MH122228NIMH NIH HHS R01 MH128235NINDS NIH HHS R01 NS102937NINDS NIH HHS R01 NS105628NINDS NIH HHS R21 NS120868
6 · The paper itself

Abstract

The prefrontal cortex coordinates experience-dependent alterations in behavioral states. In this issue of Neuron, Joffe et al. provide a novel mechanism mediating acute stress-induced biasing of information routing through the mPFC, involving mGlu5-mediated plasticity on SST interneurons and feedforward inhibition shaping input into the mPFC.

Indexed as

InterneuronsPrefrontal CortexNeurons

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.