Evidence map›Paper›PMID 35298791›Full record

ArticleEating and weight disorders : EWD2022

Evaluating the use of lamotrigine to reduce mood lability and impulsive behaviors in adults with chronic and severe eating disorders.

Erin E Reilly, Laura A Berner, Mary Ellen Trunko, Terry Schwartz, Leslie K Anderson, Angeline Krueger, Xinze Yu, Joanna Y Chen, Anne Cusack, Tiffany Nakamura and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Eating and weight disorders : EWD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Erin E Reilly *Department of Psychology, Hofstra University, Hempstead, USA.ORCID http://orcid.org/0000-0001-9269-0747
Laura A Berner *Department of Psychiatry, UCSD Health Eating Disorders Center for Research and Treatment, University of California, San Diego, San Diego, CA, USA.
Mary Ellen TrunkoDepartment of Psychiatry, UCSD Health Eating Disorders Center for Research and Treatment, University of California, San Diego, San Diego, CA, USA.
Terry SchwartzDepartment of Psychiatry, UCSD Health Eating Disorders Center for Research and Treatment, University of California, San Diego, San Diego, CA, USA.
Leslie K AndersonDepartment of Psychiatry, UCSD Health Eating Disorders Center for Research and Treatment, University of California, San Diego, San Diego, CA, USA.
Angeline KruegerDepartment of Psychiatry, UCSD Health Eating Disorders Center for Research and Treatment, University of California, San Diego, San Diego, CA, USA.
Xinze YuDepartment of Psychiatry, UCSD Health Eating Disorders Center for Research and Treatment, University of California, San Diego, San Diego, CA, USA.
Joanna Y ChenDepartment of Psychiatry, UCSD Health Eating Disorders Center for Research and Treatment, University of California, San Diego, San Diego, CA, USA.
Anne CusackDepartment of Psychiatry, UCSD Health Eating Disorders Center for Research and Treatment, University of California, San Diego, San Diego, CA, USA.
Tiffany NakamuraDepartment of Psychiatry, UCSD Health Eating Disorders Center for Research and Treatment, University of California, San Diego, San Diego, CA, USA.
Walter H KayeDepartment of Psychiatry, UCSD Health Eating Disorders Center for Research and Treatment, University of California, San Diego, San Diego, CA, USA. wkaye@ucsd.health.edu.
University of California San Diego · USHofstra University · USUC San Diego Health System · US

Funding

The Influences of Eating and Fasting on Inhibitory Control in Bulimia Nervosa: A Computational Neuroimaging StudyK23MH118418 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BERNER, LAURA A. · 2019 to 2023
$963k
Neural Bases of Self-regulatory Control in Bulimia NervosaF32MH108311 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BERNER, LAURA A. · 2016 to 2018
$171k
NIMH NIH HHS F32 MH108311NIMH NIH HHS F32MH108311NIMH NIH HHS K23 MH118418NIMH NIH HHS K23MH118418
6 · The paper itself

Abstract

backgroundGold-standard psychological and pharmacological treatments for bulimic-spectrum eating disorders only result in remission for around 50% of patients; patients with affective lability and impulsivity represent a subgroup with particularly poor outcomes. Both dialectical behavior therapy (DBT), a treatment for emotion dysregulation, and lamotrigine, a mood stabilizer, have demonstrated promise for targeting affective lability and impulsivity; however, data exploring the combination of these interventions remain limited.

objectiveWe followed a group of women with recurrent dysregulated eating behaviors (N = 62) throughout intensive DBT treatment and compared the symptom trajectory of those prescribed lamotrigine (n = 28) and those who were not (n = 34).

methodParticipants completed surveys every 2 weeks throughout treatment.

resultsGroup analyses suggested that all participants self-reported decreases in emotional reactivity, negative urgency, and symptoms of borderline personality disorder (BPD). The lamotrigine group reported greater elevations in BPD symptoms at baseline, but demonstrated steeper decreases in emotion and behavioral dysregulation than the non-matched comparison group. Within-subject analyses suggested that within the lamotrigine group, subjects reported greater decreases in symptoms following prescription of lamotrigine.

conclusionsFindings provide initial data suggesting that lamotrigine could be useful as an adjunctive treatment for patients with affective lability and impulsivity. LEVEL OF EVIDENCE: IV, time series without randomization.

Indexed as

Borderline Personality DisorderFeeding and Eating DisordersAdultAffective SymptomsFemaleHumansImpulsive BehaviorLamotrigineLamotrigineAnorexia nervosaBulimia nervosaEmotion dysregulationImpulsivityLamotrigine

Identifiers

PMID35298791
PMCPMC9123051
OpenAlexW4220682001

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.