Evidence map›Paper›PMID 35298733›Full record

ArticleMycopathologia2022

Candidemia in Internal Medicine: Facing the New Challenge.

Lucia Brescini, Sara Mazzanti, Gianluca Morroni, Francesco Pallotta, Annamaria Masucci, Elena Orsetti, Roberto Montalti, Francesco Barchiesi

Open access · hybridAbstract read
In one paragraph

Article in Mycopathologia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Analysis of clinicalAntimicrobial agents and chemotherapy · 2024
    Article
  9. Candida parapsilosis complex in the clinical setting.Nature reviews. Microbiology · 2024
    Review
  10. Analysis of clinicalbioRxiv : the preprint server for biology · 2023
    Article
  11. Article
  12. Article
  13. Multicentre Surveillance ofMicroorganisms · 2023
    Article
  14. Candidiasis and Other Emerging Yeasts.Current fungal infection reports · 2023
    Review
  15. Antifungal Combinations againstJournal of fungi (Basel, Switzerland) · 2022
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Lucia BresciniDipartimento di Scienze Biomediche e Sanità Pubblica, Università Politecnica delle Marche, Ancona, Italy.
Sara MazzantiDipartimento di Scienze Biomediche e Sanità Pubblica, Università Politecnica delle Marche, Ancona, Italy.
Gianluca MorroniDipartimento di Scienze Biomediche e Sanità Pubblica, Università Politecnica delle Marche, Ancona, Italy.
Francesco PallottaDipartimento di Scienze Biomediche e Sanità Pubblica, Università Politecnica delle Marche, Ancona, Italy.
Annamaria MasucciLaboratorio di Microbiologia, Azienda Ospedaliera Universitaria Ospedali Riuniti Umberto I°-Lancisi-Salesi, Ancona, Italy.
Elena OrsettiAzienda Ospedaliera Universitaria Ospedali Riuniti Umberto I°-Lancisi-Salesi, Ancona, Italy.
Roberto MontaltiUnità di Chirurgia Epato-Bilio-Pancreatica, Mininvasiva e Robotica, Dipartimento di Sanità Pubblica, Università Federico II, Napoli, Italy.
Francesco BarchiesiDipartimento di Scienze Biomediche e Sanità Pubblica, Università Politecnica delle Marche, Ancona, Italy. f.barchiesi@univpm.it.ORCID http://orcid.org/0000-0003-1098-902X
Marche Polytechnic University · ITOspedali Riuniti Umberto I · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Candidemia is an alarming problem in critically ill patients including those admitted in Internal Medicine Wards (IMWs). Here, we analyzed all cases of candidemia in adult patients hospitalized over nine years (2010-2018) in IMWs of a 980-bedded University Hospital of Ancona, Italy. During the study period, 218/505 (43%) episodes of candidemia occurred in IMWs patients. The cumulative incidence was 2.5/1000 hospital admission and increased significantly over time (p = 0.013). Patients were predominantly male, with a median age of 68 years. Cardiovascular diseases and solid tumors were the most frequent comorbidities. Candida albicans accounted for 51% of the cases, followed by C. parapsilosis (25%), C. tropicalis (9%) and C. glabrata (7%). Thirty-day mortality was 28% and did not increased significantly over time. By multivariate logistic regression analysis, the presence of neutropenia (OR 7.247 [CI95% 1,368-38,400; p = 0.020]), pneumonia (OR 2.323 [CI95% 1,105-4,884; p = 0.026]), and being infected with C. albicans (OR 2.642 [95% CI 1,223-5,708; p = 0.013) emerged as independent predictors of mortality. The type of antifungal therapy did not influence the outcome. Overall, these data indicate that patients admitted to IMWs are increasingly at higher risk of developing candidemia. Mortality rate remains high and significantly associated with both microbiologic- and host-related factors.

Indexed as

CandidemiaAdultAgedAntifungal AgentsCandidaCandida albicansCandida glabrataCandida parapsilosisCandida tropicalisFemaleHospitals, UniversityHumansMaleRetrospective StudiesRisk FactorsAntifungal AgentsAntifungal agentsAntifungal susceptibility testingCandida albicansCandidemiaInternal medicine

Identifiers

PMID35298733
PMCPMC9124164
OpenAlexW4221111199

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.