Evidence map›Paper›PMID 35298700›Full record

SynthesisClinical research in cardiology : official journal of the German Cardiac Society2022

A systematic review and meta-analysis of the cerebrovascular event incidence after transcatheter aortic valve implantation.

Max M Meertens, Sascha Macherey, Sebastiaan Asselberghs, Samuel Lee, Jan Hendrik Schipper, Barend Mees, Ingo Eitel, Stephan Baldus, Christian Frerker, Tobias Schmidt

Erratum issuedAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical research in cardiology : official journal of the German Cardiac Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Article
  3. Observational
  4. [Experience of the use of cerebral embolic protection device during transcatheter aortic valve replacement].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
    Article
  5. Review
  6. [Advances in stroke after transcatheter aortic valve replacement].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
    Review
  7. Non-femoral focused transaxillary access in TAVI: GARY data analysis and future trends.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
    Article
  8. Review
  9. Cerebrovascular events after transcatheter aortic valve implantation.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Max M MeertensDepartment III of Internal Medicine, University Hospital of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0002-7746-8723
Sascha MachereyDepartment III of Internal Medicine, University Hospital of Cologne, Cologne, Germany.
Sebastiaan AsselberghsDepartment of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands.
Samuel LeeDepartment III of Internal Medicine, University Hospital of Cologne, Cologne, Germany.
Jan Hendrik SchipperDepartment III of Internal Medicine, University Hospital of Cologne, Cologne, Germany.
Barend MeesDepartment of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands.
Ingo EitelDepartment of Cardiology, Angiology and Intensive Care Medicine, University Heart Center Lübeck, University Hospital Schleswig-Holstein, Ratzeburger Allee 160, 23538, Lübeck, Germany.
Stephan BaldusDepartment III of Internal Medicine, University Hospital of Cologne, Cologne, Germany.
Christian Frerker *Department of Cardiology, Angiology and Intensive Care Medicine, University Heart Center Lübeck, University Hospital Schleswig-Holstein, Ratzeburger Allee 160, 23538, Lübeck, Germany.
Tobias Schmidt *Department of Cardiology, Angiology and Intensive Care Medicine, University Heart Center Lübeck, University Hospital Schleswig-Holstein, Ratzeburger Allee 160, 23538, Lübeck, Germany. tobiasschmidtmd@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePeriinterventional stroke is one of the most feared potential complication, among patients treated with transcatheter aortic valve implantation (TAVI). The purpose of this review was to investigate the incidence of cerebrovascular events and the influence of postinterventional neurologic check-up in patients undergoing TAVI.

methodsA systematic review and meta-analysis were conducted according to the PRISMA guideline. Three separate electronic searches of the public domains Medline and Clinicaltrials.gov were performed to identify the 30-day incidence of stroke within randomized controlled trials (RCTs) and registries for patients undergoing a TAVI procedure. A meta-analysis was conducted to evaluate the 30-day incidence of stroke within RCTs. Furthermore, we pooled the RCTs in which a scheduled neurological check-up was conducted or not to investigate the effect of this intervention.

resultsTwenty-three studies including 399,491 TAVI patients were included, 6370 from RCTs, 833 from cerebral-embolic protection device RCTs and 392,288 were adopted from registries. The mean 30-day incidence of stroke among all reviewed studies was 2.33%. In RCTs evaluating TAVI the pooled stroke incidence was 3.86%, among RCTs focused CEP the incidence was 6.36% and in registries the incidence was 2.29%. Ten RCTs conducted scheduled neurological check-ups, the incidence in these was 4.03% and among the remaining RCTs it was 2.47%. In the meta-analysis, the pooled 30-day stroke incidence was 3.61% (95% CI 2.57-4.79%).

conclusionThis systematic review demonstrates that the stroke incidences following TAVI differ strongly according to the study design and neurological follow-up. Intense neurological testing increases the incidence of a stroke after TAVI.

Indexed as

Aortic Valve StenosisHeart Valve Prosthesis ImplantationStrokeTranscatheter Aortic Valve ReplacementAortic ValveHumansIncidenceRegistriesRisk FactorsTreatment OutcomeAortic stenosisCerebral protection deviceStrokeTranscatheter aortic valve implantationTranscatheter aortic valve replacement

Identifiers

PMID35298700

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.