Evidence map›Paper›PMID 35298669›Full record

ReviewInflammation research : official journal of the European Histamine Research Society ... [et al.]2022

Role of the innate and adaptive immune responses in the pathogenesis of systemic lupus erythematosus.

Nasim Bolouri, Maryam Akhtari, Elham Farhadi, Reza Mansouri, Seyedeh Tahereh Faezi, Ahmadreza Jamshidi, Mahdi Mahmoudi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
9.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nasim BolouriImmunology Department, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Maryam AkhtariRheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Elham FarhadiRheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. farhadie@tums.ac.ir.ORCID http://orcid.org/0000-0002-4324-2697
Reza MansouriImmunology Department, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Seyedeh Tahereh FaeziRheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Ahmadreza JamshidiRheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Mahdi MahmoudiRheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Shariati Hospital · IRShahid Sadoughi University of Medical Sciences and Health Services · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSystemic lupus erythematosus (SLE), the most common form of lupus, is a multisystemic rheumatic disease with different clinical features that generally affect women of childbearing age. The common symptoms of SLE are very similar to other autoimmune and non-autoimmune disorders, thereby it is known as a thousand faces disease. In this article, we are going to discuss some of the most updated information about immune system-related factors, cells, and cytokines involved in SLE pathogenesis.

methodsDifferent electronic databases, especially PubMed/MEDLINE, Scopus, and Google Scholar, were searched to review and analyze relevant literature on the role of innate and adaptive immune cells and cytokines in the pathogenesis of SLE. A search for relevant literature was accomplished using various keywords including systemic lupus erythematosus, apoptosis, autoantibodies, immunopathogenesis of SLE, adaptive and innate immune cells, inflammatory cytokines, hormones, etc. RESULTS AND

conclusionThe most important characteristic of SLE is the production of antibodies against different nuclear autoantigens like double-strand DNA and RNA. The depositions of the immune complexes (ICs) that are generated between autoantibodies and autoantigens, along with aberrant clearance of them, can lead to permanent inflammation and contribute to tissue or organ damage. Related mechanisms underlying the initiation and development of SLE have not been clarified yet. Although, defects in immune tolerance, enhanced antigenic load, hyperactivity of T cells, and inappropriate regulation of B cells contribute to the pathogenic autoantibodies generation. Besides, sex hormones that influence the immune system seem to act as triggers or protectors of SLE development.

Indexed as

Adaptive ImmunityImmunity, InnateLupus Erythematosus, SystemicAutoantibodiesAutoantigensCytokinesFemaleHumansT-LymphocytesAutoantibodiesAutoantigensCytokinesCytokinesImmune cellsImmunopathogenesisSystemic lupus erythematosus

Identifiers

PMID35298669
OpenAlexW4220815386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.