Evidence map›Paper›PMID 35298533›Full record

ArticlePloS one2022

Skin and nasal colonization of coagulase-negative staphylococci are associated with atopic dermatitis among South African toddlers.

Gillian O N Ndhlovu, Felix S Dube, Rasalika T Moonsamy, Avumile Mankahla, Carol Hlela, Michael E Levin, Nonhlanhla Lunjani, Adebayo O Shittu, Shima M Abdulgader

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Gillian O N NdhlovuDepartment of Molecular and Cell Biology, Faculty of Science, University of Cape Town, Cape Town, South Africa.ORCID 0000-0001-7188-5772
Felix S DubeDepartment of Molecular and Cell Biology, Faculty of Science, University of Cape Town, Cape Town, South Africa.
Rasalika T MoonsamyDepartment of Molecular and Cell Biology, Faculty of Science, University of Cape Town, Cape Town, South Africa.
Avumile MankahlaDepartment of Medicine and Pharmacology, Division of Dermatology, Walter Sisulu University, Umtata, South Africa.
Carol HlelaDepartment of Paediatric, Division of Paediatric Allergy, University of Cape Town, Cape Town, South Africa.
Michael E LevinDepartment of Paediatric, Division of Paediatric Allergy, University of Cape Town, Cape Town, South Africa.
Nonhlanhla LunjaniDepartment of Paediatric, Division of Paediatric Allergy, University of Cape Town, Cape Town, South Africa.
Adebayo O ShittuDepartment of Microbiology, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.ORCID 0000-0003-3992-4123
Shima M AbdulgaderDepartment of Biomedical Sciences, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
University of Cape Town · ZAStellenbosch University · ZAUniversity Hospital Münster · DEWalter Sisulu University · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSkin colonization with coagulase-negative staphylococci (CoNS) is generally beneficial, but recent investigations suggest its association with flares and atopic dermatitis (AD) severity. However, this relationship remains unclear.

objectiveTo assess patterns of staphylococcal colonization and biofilm formation in toddlers with and without AD from rural and urban South African settings.

methodsWe conducted a cross-sectional study of AD-affected and non-atopic AmaXhosa toddlers from rural Umtata and urban Cape Town, South Africa. CoNS isolates were recovered from lesional, nonlesional skin samples and the anterior nares of participants. Identification of the staphylococci was achieved by MALDI-TOF mass spectrometry. The microtiter plate assay assessed in-vitro biofilm formation.

resultsCoNS and S. aureus commonly co-colonized nonlesional skin among cases (urban: 24% vs. 3%, p = 0.037 and rural 21% vs. 6%, p<0.001), and anterior nares in urban cases (24% vs. 0%, p = 0.002) than the control group. S. capitis colonization on nonlesional skin and anterior nares was positively associated with more severe disease in rural (48.3±10.8 vs. 39.7±11.5, P = 0.045) and urban cases (74.9±10.3 vs. 38.4±13, P = 0.004), respectively. Biofilm formation was similar between cases and controls, independent of rural-urban living.

conclusionCoNS colonization is associated with AD and disease severity and may be implicated in AD exacerbations. Studies are needed to understand their underlying pathological contribution in AD pathogenesis.

Indexed as

Dermatitis, AtopicStaphylococcal InfectionsChild, PreschoolCoagulaseCross-Sectional StudiesHumansSkinSouth AfricaStaphylococcusStaphylococcus aureusCoagulase

Identifiers

PMID35298533
PMCPMC8929619
OpenAlexW4220898544

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.