Evidence map›Paper›PMID 35298245›Full record

ArticleScience (New York, N.Y.)2022

Direct observation of adaptive tracking on ecological time scales in

Seth M Rudman, Sharon I Greenblum, Subhash Rajpurohit, Nicolas J Betancourt, Jinjoo Hanna, Susanne Tilk, Tuya Yokoyama, Dmitri A Petrov, Paul Schmidt

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 2 pooled it
34.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 2 syntheses or guidelines pooled it, 198 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
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  8. Article
  9. Beyond Fixation: Persistent Genetic Variation Under Intense Selection.bioRxiv : the preprint server for biology · 2026
    Article
  10. Climate predictsbioRxiv : the preprint server for biology · 2026
    Article
  11. Article
  12. Article
  13. Evolution of species' range and niche in changing environments.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. A century of theories of balancing selection.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
  18. Article
  19. Article
  20. Article

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Seth M Rudman *Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-5816-2801
Sharon I Greenblum *Department of Biology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0001-6148-3016
Subhash Rajpurohit *Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-9149-391X
Nicolas J BetancourtDepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-8768-9829
Jinjoo HannaDepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-1909-7423
Susanne TilkDepartment of Biology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-9156-9360
Tuya YokoyamaDepartment of Biology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-3340-0898
Dmitri A PetrovDepartment of Biology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-3664-9130
Paul SchmidtDepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-8076-6705
Stanford University · USUniversity of Pennsylvania · USAhmedabad University · INLawrence Berkeley National Laboratory · USWashington State University Vancouver · US

Funding

Genomics of rapid adaptation in the lab and in the wildR35GM118165 · NIGMS · STANFORD UNIVERSITY · PI Dmitri Petrov · 2016 to 2026
$8.3M
Genomics of rapid adaptation on seasonal timescales in D. melanogasterR01GM100366 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI SCHMIDT, PAUL · 2012 to 2019
$3.3M
Rapid evolution of pigmentation in D. melanogaster: from cis regulation to phenotypeR01GM137430 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI MCINTYRE, LAUREN M., SCHMIDT, PAUL · 2021 to 2024
$2.2M
The genome architecture of rapid adaptation in Drosophila melanogasterF32GM122216 · NIGMS · STANFORD UNIVERSITY · PI GREENBLUM, SHARON · 2017 to 2018
$110k
NIGMS NIH HHS F32 GM122216NIGMS NIH HHS R01 GM100366NIGMS NIH HHS R01 GM137430NIGMS NIH HHS R35 GM118165
6 · The paper itself

Abstract

Direct observation of evolution in response to natural environmental change can resolve fundamental questions about adaptation, including its pace, temporal dynamics, and underlying phenotypic and genomic architecture. We tracked the evolution of fitness-associated phenotypes and allele frequencies genome-wide in 10 replicate field populations of

Indexed as

AcclimatizationBiological EvolutionSelection, GeneticAnimalsDrosophila melanogasterEcosystemEnvironmentEvolution, MolecularGene FrequencyGenetic FitnessGenome, InsectPhenotypeSeasons

Identifiers

PMID35298245
PMCPMC10684103
OpenAlexW4221132928

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.