ArticleMicrobiology spectrum2022
The Role of Plasmid and Resistance Gene Acquisition in the Emergence of ST23 Multi-Drug Resistant, Hypervirulent Klebsiella pneumoniae.
Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Systematic review and meta-analysis on the carbapenem-resistant hypervirulent Klebsiella pneumoniae isolates.BMC pharmacology & toxicology · 2025Pooled it
- Evaluating long-read metagenomics for bloodstream infection diagnostics: a pilot study from a Thai Tertiary Hospital.Scientific reports · 2026Article
- Carbapenemase-producing hypervirulentJournal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2026Article
- Differential gut transmission of IncP plasmid clades involving hypervirulent Klebsiella pneumoniae reveals plasmid-specific ecological adaptation.Nature communications · 2025Article
- Anti-plasmid defense in hypervirulentEmerging microbes & infections · 2025Article
- Mechanistic insights into the formation and spread of carbapenem-resistant hypervirulentMicrobial genomics · 2025Article
- Lineage-specific evolution and resistance-virulence divergence inAntimicrobial agents and chemotherapy · 2025Article
- K1 Klebsiella pneumoniae is more conserved than K2 for both virulence plasmid and chromosome.BMC genomics · 2025Article
- ESBL-ProducingMicroorganisms · 2025Article
- Extended-spectrum beta-lactamases: definition, history, an update on their genetic environment and detection methods.Journal of medical microbiology · 2025Review
- Molecular and virulence differences ofFrontiers in microbiology · 2025Article
- Emergence of a novel sequence type carbapenem-resistant hypervirulentMicrobiology spectrum · 2024Article
- Article
- ST218 Klebsiella pneumoniae became a high-risk clone for multidrug resistance and hypervirulence.BMC microbiology · 2024Article
- Molecular Characteristics of Virulence Genes in Carbapenem-Resistant and Carbapenem-SensitiveInfection and drug resistance · 2024Article
- Fusion plasmid enhanced the endemic extensively drug resistant Klebsiella pneumoniae clone ST147 harbored blaAnnals of clinical microbiology and antimicrobials · 2023Article
- Clinical Characteristics and Molecular Epidemiology of ST23Infection and drug resistance · 2023Article
- Comparative Genomic Analysis of Hypervirulence Carbapenem-ResistantInfection and drug resistance · 2023Article
- Article
- Molecular epidemiology and clinical characteristics of the type VI secretion system inFrontiers in microbiology · 2023Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multidrug-resistant (MDR) hypervirulent Klebsiella pneumoniae (hvKp) sequence type (ST) 23 (MDR-ST23-hvKp) is emerging in China. Despite its increasing importance, this pathogen has not yet been subject to detailed genomic interrogation. We identified 28 ST23 Kp isolated from three hospitals in China. The organisms were subjected to antimicrobial susceptibility testing and whole-genome sequencing (WGS). These novel genomic sequences were analyzed in combination with 218 publicly available genome sequences. We performed molecular serotyping and subtyping, assessed the composition of virulence-associated and antimicrobial resistance (AMR) genes, and determined mobile elements associated with horizontal gene transfer. Two MDR-ST23-hvKp were sequenced by long-read sequencing. The genetic characteristics of MDR and non-MDR isolates were compared. Among the 28 novel ST23 isolates, all were hvKp and 2/28 (7.1%) were MDR-hvKp. From the collection of 246 genomes, KL1 was the predominant serotype (224/246; 91.1%) and the siderophore combination of YbST46-CbST29-AbST1-SmST2 was dominant (101/246; 41.1%); 34/246 (13.8%) organisms belonged to MDR-ST23-hvKp. IncF and IncR plasmid replicons were significantly more prevalent in the MDR group (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.