Evidence map›Paper›PMID 35297652›Full record

ArticleMicrobiology spectrum2022

CpxA Phosphatase Inhibitor Activates CpxRA and Is a Potential Treatment for Uropathogenic Escherichia coli in a Murine Model of Infection.

Kate R Fortney, Sara N Smith, Julia J van Rensburg, Julie A Brothwell, Jessi J Gardner, Barry P Katz, Nagib Ahsan, Adam S Duerfeldt, Harry L T Mobley, Stanley M Spinola

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Anti-infective compounds forSustainable microbiology · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Cpx-signalling innpj antimicrobials and resistance · 2024
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Kate R Fortney *Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Sara N Smith *Department of Microbiology and Immunology, University of Michigan Medical Schoolgrid.471406.0, Ann Arbor, Michigan, USA.
Julia J van RensburgDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Julie A BrothwellDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-5277-3692
Jessi J GardnerDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.
Barry P KatzDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Nagib AhsanDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.
Adam S DuerfeldtDepartment of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-3130-9890
Harry L T MobleyDepartment of Microbiology and Immunology, University of Michigan Medical Schoolgrid.471406.0, Ann Arbor, Michigan, USA.
Stanley M SpinolaDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0003-3435-9911
Indiana University School of MedicineUniversity of Michigan · USUniversity of Oklahoma · USUniversity of Minnesota · US

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Sara K Quinney · 1999 to 2026
$59.3M
Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Predictive Models for Small-Molecule Accumulation in Gram-Negative BacteriaR01AI136795 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI TAN, DEREK S, ZGURSKAYA, HELEN I · 2018 to 2022
$6.5M
PATHOGENESIS OF HAEMOPHILUS DUCREYI INFECTIONSR01AI027863 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SPINOLA, STANLEY M. · 1995 to 2013
$3.8M
NCATS NIH HHS UL1 TR002529NCI NIH HHS P30 CA082709NIAID NIH HHS R01 AI027863NIAID NIH HHS R01 AI136795
6 · The paper itself

Abstract

CpxRA is an envelope stress response system that is highly conserved in the

Indexed as

Escherichia coli InfectionsEscherichia coli ProteinsUrinary Tract InfectionsUropathogenic Escherichia coliAnimalsAnti-Bacterial AgentsBacterial ProteinsDisease Models, AnimalFemaleGene Expression Regulation, BacterialHumansMaleMicePhosphoric Monoester HydrolasesProtein KinasesSalmonella typhimuriumAnti-Bacterial AgentsBacterial ProteinsCpxA protein, E coliEscherichia coli ProteinsPhosphoric Monoester HydrolasesProtein KinasesVirulence FactorsCpxRAEscherichia coliphosphatase inhibitortreatmentUPEC

Identifiers

PMID35297652
PMCPMC9045377
OpenAlexW4220714825

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.