Evidence map›Paper›PMID 35297629›Full record

ArticleJournal of the American Chemical Society2022

Computational Prediction and Experimental Validation of a Bridged Cation Intermediate in Akanthomycin Biosynthesis.

Cooper S Jamieson, Masao Ohashi, K N Houk, Yi Tang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Robust Stitching Interface and Deep Learning Empowered Hydrogel Human-Machine Interface.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Cooper S JamiesonDepartment of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California 90095, United States.ORCID 0000-0002-6076-6230
Masao OhashiDepartment of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, California 90095, United States.ORCID 0000-0001-7103-541X
K N HoukDepartment of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California 90095, United States.ORCID 0000-0002-8387-5261
Yi TangDepartment of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California 90095, United States.ORCID 0000-0003-1597-0141
University of California, Los Angeles · US

Funding

Biosynthesis and Enzymology of Antifungal Natural Products - R01AI141481R01AI141481 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GARG, NEIL K, HOUK, KENDALL N · 2019 to 2023
$2.8M
NIAID NIH HHS R01 AI141481
6 · The paper itself

Abstract

Here we report a computation-driven chemoenzymatic synthesis and biosynthesis of the natural product deoxyakanthomycin, an atropisomeric pyridone natural product that features a 7-membered carbocycle with five stereocenters, one of which a quaternary center. The one-step synthesis from a biosynthetic precursor is based on computational analysis that predicted a σ-bridged cation mediated cyclization mechanism to form deoxyakanthomycin. The σ-bridged cation rationalizes the observed substrate-controlled selectivity; diastereoselectivity arises from attack of water

Indexed as

Biological ProductsPyridonesCationsCyclizationakanthomycinBiological ProductsCationsPyridones

Identifiers

PMID35297629
PMCPMC9128357
OpenAlexW4220933790

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.