ArticleCerebral cortex (New York, N.Y. : 1991)2022
Novelty-induced frontal-STN networks in Parkinson's disease.
Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06984757 (Mid-frontal Delta/Theta and Cognitive Control), which is not on this map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mid-frontal Delta/Theta and Cognitive Control
Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Cognitive trajectories in Parkinson's disease patients, a review on the impact of subthalamic deep brain stimulation (STN-DBS) and emerging adaptive strategies.Translational psychiatry · 2026Review
- Cortical connectivity is associated with cognition across time in Parkinson's disease.Neuroimage. Reports · 2025Article
- Resting-state EEG measures cognitive impairment in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Evoked mid-frontal activity predicts cognitive dysfunction in Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry · 2023Article
- Salience network and cognitive impairment in Parkinson's disease.medRxiv : the preprint server for health sciences · 2023Article
- A Pilot Study of Ex Vivo Human Prefrontal RNA Transcriptomics in Parkinson's Disease.Cellular and molecular neurobiology · 2023Article
- Abnormal neural oscillations during gait and dual-task in Parkinson's disease.Frontiers in systems neuroscience · 2022Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Novelty detection is a primitive subcomponent of cognitive control that can be deficient in Parkinson's disease (PD) patients. Here, we studied the corticostriatal mechanisms underlying novelty-response deficits. In participants with PD, we recorded from cortical circuits with scalp-based electroencephalography (EEG) and from subcortical circuits using intraoperative neurophysiology during surgeries for implantation of deep brain stimulation (DBS) electrodes. We report three major results. First, novel auditory stimuli triggered midfrontal low-frequency rhythms; of these, 1-4 Hz "delta" rhythms were linked to novelty-associated slowing, whereas 4-7 Hz "theta" rhythms were specifically attenuated in PD. Second, 32% of subthalamic nucleus (STN) neurons were response-modulated; nearly all (94%) of these were also modulated by novel stimuli. Third, response-modulated STN neurons were coherent with midfrontal 1-4 Hz activity. These findings link scalp-based measurements of neural activity with neuronal activity in the STN. Our results provide insight into midfrontal cognitive control mechanisms and how purported hyperdirect frontobasal ganglia circuits evaluate new information.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.