Evidence map›Paper›PMID 35297170›Full record

ReviewInternational wound journal2022

Emerging treatment strategies in wound care.

Marjan Mirhaj, Sheyda Labbaf, Mohamadreza Tavakoli, Alexander Marcus Seifalian

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in International wound journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05883098 (Effectiveness of Supra SDRM® vs. Fibracol Plus Collagen in the Treatment of Diabetic Foot Ulcers), which is not on this map. Cited by 78 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 2 pooled it
18.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05883098 nacompletednot on this map

Effectiveness of Supra SDRM® vs. Fibracol Plus Collagen in the Treatment of Diabetic Foot Ulcers: a Pilot Randomized Controlled Trial

TypeinterventionalSponsorPolymedics Innovations Inc.Ran2022 to 2023Enrolled30ConditionsDiabetic Foot, Ulcer Foot, Wound HealArmsWound debridement, Wound closure matrix application
3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 2 syntheses or guidelines pooled it, 194 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Role of South African Community Pharmacists in Wound Care: An Exploratory Study.International journal of environmental research and public health · 2026
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Role of a topical hydrogel (DermatixDrugs in context · 2026
    Review
  15. Review
  16. Review
  17. Biocompatibility Issues of Wound Dressings.Bioengineering (Basel, Switzerland) · 2025
    Article
  18. Review
  19. Review
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Marjan MirhajDepartment of Materials Engineering, Isfahan University of Technology, Isfahan, Iran.
Sheyda LabbafDepartment of Materials Engineering, Isfahan University of Technology, Isfahan, Iran.ORCID https://orcid.org/0000-0003-1555-3874
Mohamadreza TavakoliDepartment of Materials Engineering, Isfahan University of Technology, Isfahan, Iran.
Alexander Marcus SeifalianNanotechnology & Regenerative Medicine Commercialization Centre (NanoRegMed Ltd), London BioScience Innovation Centre, London, UK.ORCID https://orcid.org/0000-0002-8334-9376
Isfahan University of Technology · IRLondon Centre for Nanotechnology · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wound healing is a complex process in tissue regeneration through which the body responds to the dissipated cells as a result of any kind of severe injury. Diabetic and non-healing wounds are considered an unmet clinical need. Currently, different strategic approaches are widely used in the treatment of acute and chronic wounds which include, but are not limited to, tissue transplantation, cell therapy and wound dressings, and the use of an instrument. A large number of literatures have been published on this topic; however, the most effective clinical treatment remains a challenge. The wound dressing involves the use of a scaffold, usually using biomaterials for the delivery of medication, autologous stem cells, or growth factors from the blood. Antibacterial and anti-inflammatory drugs are also used to stop the infection as well as accelerate wound healing. With an increase in the ageing population leading to diabetes and associated cutaneous wounds, there is a great need to improve the current treatment strategies. This research critically reviews the current advancement in the therapeutic and clinical approaches for wound healing and tissue regeneration. The results of recent clinical trials suggest that the use of modern dressings and skin substitutes is the easiest, most accessible, and most cost-effective way to treat chronic wounds with advances in materials science such as graphene as 3D scaffold and biomolecules hold significant promise. The annual market value for successful wound treatment exceeds over $50 billion US dollars, and this will encourage industries as well as academics to investigate the application of emerging smart materials for modern dressings and skin substitutes for wound therapy.

Indexed as

BandagesSkin, ArtificialBiocompatible MaterialsHumansIntercellular Signaling Peptides and ProteinsWound HealingBiocompatible MaterialsIntercellular Signaling Peptides and Proteinscells therapyplatelet therapyskin tissue engineeringwound dressingwound healing

Identifiers

PMID35297170
PMCPMC9615294
OpenAlexW4221045956

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.