Observational studyRespirology (Carlton, Vic.)2022
Prognosis assessment model based on low serum calcium in patients with acute pulmonary thromboembolism.
Observational study in Respirology (Carlton, Vic.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 14 citations in OpenAlex.
- Prognostic Score Model for 30-Day Mortality in Patients with Acute Pulmonary Embolism Presenting to the Emergency Department.Diagnostics (Basel, Switzerland) · 2026Article
- Association between serum calcium and in-hospital mortality in patients with severe fever with thrombocytopenia syndrome: a retrospective cohort study.Virology journal · 2026Article
- Association Between Preoperative Calcium Levels and the Occurrence of Postoperative PE in Trauma Patients: A Retrospective Multicenter Cohort Study.World journal of surgery · 2026Article
- Development and Evaluation of an Innovative Inflammatory Prognostic Score for Predicting Long-Term Mortality in Patients With Pulmonary Embolism.Mediators of inflammation · 2025Article
- Federated-learning-based prognosis assessment model for acute pulmonary thromboembolism.BMC medical informatics and decision making · 2024Article
- The association between albumin-corrected calcium and prognosis in patients with cardiac arrest: a retrospective study based on the MIMIC-IV database.European journal of medical research · 2024Article
- Additive prognostic value of serum calcium to the ESC risk stratification in patients with acute pulmonary embolism.Thrombosis journal · 2023Article
- Prognosis assessment model based on low serum calcium in patients with acute pulmonary thromboembolism.Respirology (Carlton, Vic.) · 2022Observational
- Non-linear relationship between albumin-corrected calcium and 30-day in-hospital mortality in ICU patients: A multicenter retrospective cohort study.Frontiers in endocrinology · 2022Article
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Authors and funding
14 authors at 11 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveThe pulmonary embolism severity index (PESI) and simplified PESI (sPESI) are recommended to recognize patients with acute pulmonary thromboembolism (PTE) with low prognosis risk, which is of great significance for treatment. This study aims to verify the influence of hypocalcaemia on the prognosis of patients with PTE and to establish a new prognosis assessment model.
methodsThis is an observational, multicentre study enrolling patients with PTE from February 2010 to June 2020 across 12 Chinese hospitals. Variables in PESI, serum calcium levels and patient survival status as of 5 July 2020 were collected. The area under the curve of the receiver operating characteristic curve, sensitivity, specificity and Youden index were used to evaluate model performance.
resultsIn the cohort of 4196 patients with PTE, independent associations existed between hypocalcaemia and mid- and long-term mortalities (p <0.05). By including hypocalcaemia, the new 30-day death risk prediction rule, Peking Union Medical College Hospital rule (PUMCH rule), showed significantly higher specificity (0.622 [0.582, 0.661]; p <0.001) than the PESI (0.514 [0.473, 0.554]) and sPESI (0.484 [0.444, 0.525]) and similar sensitivity (0.963 [0.810, 0.999]; p = 0.161) with PESI (0.889 [0.708, 0.976]) and sPESI (0.963 [0.810, 0.999]) in the internal validation cohort. Well-performing predictive validity was also verified on a constructed external validation cohort.
conclusionHypocalcaemia is independently associated with mid- and long-term PTE mortalities. The PUMCH rule showed significantly higher specificity than the PESI and sPESI and similar sensitivity, which may be used as a prognostic assessment tool for patients with acute PTE.
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