Evidence map›Paper›PMID 35297117›Full record

ReviewNMR in biomedicine2023

Applications of chemical exchange saturation transfer magnetic resonance imaging in identifying genetic markers in gliomas.

Shanshan Jiang, Zhibo Wen, Sung Soo Ahn, Kejia Cai, Daniel Paech, Charles G Eberhart, Jinyuan Zhou

Open access · hybridAbstract readReview
In one paragraph

Review in NMR in biomedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Review
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  9. TNMR in biomedicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Shanshan JiangDivision of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.
Zhibo WenDepartment of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Sung Soo AhnDepartment of Radiology and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, South Korea.
Kejia CaiDepartment of Radiology, University of Illinois at Chicago, Chicago, Illinois, USA.
Daniel PaechDepartment of Radiology, German Cancer Research Center, Heidelberg, Germany.
Charles G EberhartDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Jinyuan ZhouDivision of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.
Johns Hopkins University · USGerman Cancer Research Center · DESouthern Medical University · CNUniversity of Illinois Chicago · USYonsei University · KR

Funding

Quantitative CEST MRI for GBM Early Response Prediction and Biopsy GuidanceR37CA248077 · NCI · JOHNS HOPKINS UNIVERSITY · PI Shanshan Jiang · 2021 to 2026
$2.2M
Amide Proton Transfer (APT) MRI of Brain Tumors at 3TR01CA228188 · NCI · JOHNS HOPKINS UNIVERSITY · PI ZHOU, JINYUAN · 2019 to 2022
$1.6M
NCI NIH HHS R01 CA228188NCI NIH HHS R37 CA248077
6 · The paper itself

Abstract

Chemical exchange saturation transfer (CEST) imaging is an important molecular magnetic resonance imaging technique that can image numerous low-concentration biomolecules with water-exchangeable protons (such as cellular proteins) and tissue pH. CEST, or more specially amide proton transfer-weighted imaging, has been widely used for the detection, diagnosis, and response assessment of brain tumors, and its feasibility in identifying molecular markers in gliomas has also been explored in recent years. In this paper, after briefing on the basic principles and quantification methods of CEST imaging, we review its early applications in identifying isocitrate dehydrogenase mutation status, MGMT methylation status, 1p/19q deletion status, and H3K27M mutation status in gliomas. Finally, we discuss the limitations or weaknesses in these studies.

Indexed as

Brain NeoplasmsGliomaGenetic MarkersHumansIsocitrate DehydrogenaseMagnetic Resonance ImagingProtonsGenetic MarkersIsocitrate DehydrogenaseProtons1p19qAPTw imagingCEST imaginggliomaIDH mutation

Identifiers

PMID35297117
PMCPMC10557022
OpenAlexW4221037155

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.