Evidence map›Paper›PMID 35297114›Full record

ArticleNMR in biomedicine2022

Multiple sclerosis cortical lesion detection with deep learning at ultra-high-field MRI.

Francesco La Rosa, Erin S Beck, Josefina Maranzano, Ramona-Alexandra Todea, Peter van Gelderen, Jacco A de Zwart, Nicholas J Luciano, Jeff H Duyn, Jean-Philippe Thiran, Cristina Granziera and 3 more

Open access · hybridAbstract read
In one paragraph

Article in NMR in biomedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
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  10. Article
  11. Decoding Gray Matter Involvement in Multiple Sclerosis via Imaging.Neuroimaging clinics of North America · 2024
    Review
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  13. Review
  14. Review
  15. Review
  16. Article
  17. Leptomeningeal enhancement in multiple sclerosis demonstrates posterior predilection and TMultiple sclerosis journal - experimental, translational and clinical
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 4 countries.

Francesco La RosaSignal Processing Laboratory (LTS5), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne.ORCID 0000-0002-9224-4664
Erin S BeckTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.
Josefina MaranzanoDepartment of Anatomy, University of Quebec in Trois-Rivières, Trois-Rivières, Quebec, Canada.
Ramona-Alexandra TodeaDepartment of Neuroradiology, Clinic of Radiology and Nuclear Medicine, University Hospital of Basel, Basel, Switzerland.
Peter van GelderenAdvanced MRI Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Jacco A de ZwartAdvanced MRI Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Nicholas J LucianoTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.
Jeff H DuynAdvanced MRI Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Jean-Philippe ThiranSignal Processing Laboratory (LTS5), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne.
Cristina GranzieraTranslational Imaging in Neurology (ThINk) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland.
Daniel S ReichTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.
Pascal SatiTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.
Meritxell Bach CuadraCIBM Center for Biomedical Imaging.ORCID 0000-0003-2730-4285
National Institutes of Health · USCentre d'Imagerie BioMedicale · CHCedars-Sinai Medical Center · USMontreal Neurological Institute and Hospital · CAUniversity Hospital of Basel · CHUniversity of Basel · CH

Funding

Multimodal MRI in Multiple SclerosisZIANS003119 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI REICH, DANIEL · 2010 to 2025
$53.4M
Magnetic Resonance Imaging Technology DevelopmentZIANS002990 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI DUYN, JEFF · 2009 to 2025
$25.5M
6 · The paper itself

Abstract

Manually segmenting multiple sclerosis (MS) cortical lesions (CLs) is extremely time consuming, and past studies have shown only moderate inter-rater reliability. To accelerate this task, we developed a deep-learning-based framework (CLAIMS: Cortical Lesion AI-Based Assessment in Multiple Sclerosis) for the automated detection and classification of MS CLs with 7 T MRI. Two 7 T datasets, acquired at different sites, were considered. The first consisted of 60 scans that include 0.5 mm isotropic MP2RAGE acquired four times (MP2RAGE×4), 0.7 mm MP2RAGE, 0.5 mm T

Indexed as

Deep LearningMultiple SclerosisHumansMagnetic Resonance ImagingReproducibility of Results7 Tcortical lesionsdeep learningdetectionmultiple sclerosisultra-high-field MRI

Identifiers

PMID35297114
PMCPMC9539569
OpenAlexW4221072717

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.