Evidence map›Paper›PMID 35297103›Full record

ArticleJournal of veterinary internal medicine2022

Prospective study of dilated cardiomyopathy in dogs eating nontraditional or traditional diets and in dogs with subclinical cardiac abnormalities.

Lisa Freeman, John Rush, Darcy Adin, Kelsey Weeks, Kristen Antoon, Sara Brethel, Suzanne Cunningham, Luis Dos Santos, Renee Girens, Robert Goldberg and 6 more

Open access · goldAbstract read
In one paragraph

Article in Journal of veterinary internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

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  7. The Canadian veterinary journal = La revue veterinaire canadienne · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Lisa FreemanCummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.ORCID https://orcid.org/0000-0002-0569-9557
John RushCummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.ORCID https://orcid.org/0000-0002-8277-8996
Darcy AdinCollege of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.ORCID https://orcid.org/0000-0003-0972-0365
Kelsey WeeksCummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.
Kristen AntoonCummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.
Sara BrethelCollege of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.
Suzanne CunninghamCummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.
Luis Dos SantosCummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.
Renee GirensCollege of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.
Robert GoldbergDepartment of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Emily KarlinCummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.
Darleen LessardDepartment of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Katherine LopezCummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.
Camden RoubenCollege of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.
Michelle VerebCollege of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.
Vicky YangCummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.
Tufts University · USUniversity of Florida · USUniversity of Massachusetts Chan Medical School · USCharlotte School of Law · USIowa State University · US

Funding

Naturally occurring canine myxomatous mitral valve disease as a large animal model for human non-syndromic mitral valve prolapseK01OD028205 · OD · TUFTS UNIVERSITY BOSTON · PI YANG, VICKY K. · 2019 to 2023
$691k
Nestlé Purina PetCareNIH HHS K01 OD028205The Barkley Fund
6 · The paper itself

Abstract

backgroundRecent studies have investigated dogs with presumed diet-associated dilated cardiomyopathy (daDCM), but prospective studies of multiple breeds are needed. HYPOTHESIS/

objectivesTo evaluate baseline features and serial changes in echocardiography and cardiac biomarkers in dogs with DCM eating nontraditional diets (NTDs) or traditional diets (TDs), and in dogs with subclinical cardiac abnormalities (SCA) eating NTD. ANIMALS: Sixty dogs with DCM (NTD, n = 51; TDs, n = 9) and 16 dogs with SCA eating NTDs.

methodsEchocardiography, electrocardiography, and measurement of taurine, cardiac troponin I, and N-terminal pro-B-type natriuretic peptide were performed in dogs with DCM or SCA. Diets were changed for all dogs, taurine was supplemented in most, and echocardiography and cardiac biomarkers were reassessed (3, 6, and 9 months).

resultsAt enrollment, there were few differences between dogs with DCM eating NTDs or TDs; none had low plasma or whole blood taurine concentrations. Improvement in fractional shortening over time was significantly associated with previous consumption of a NTD, even after adjustment for other variables (P = .005). Median survival time for dogs with DCM was 611 days (range, 2-940 days) for the NTD group and 161 days (range, 12-669 days) for the TD group (P = .21). Sudden death was the most common cause of death in both diet groups. Dogs with SCA also had significant echocardiographic improvements over time. CONCLUSIONS AND CLINICAL IMPORTANCE: Dogs with DCM or SCA previously eating NTDs had small, yet significant improvements in echocardiographic parameters after diet changes.

Indexed as

Cardiomyopathy, DilatedDog DiseasesAnimalsDietDogsEchocardiographyProspective Studiesarrhythmiacongestive heart failuregrain-freeheart diseasenutritionpulses

Identifiers

PMID35297103
PMCPMC8965249
OpenAlexW4220754038

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.