Evidence map›Paper›PMID 35297036›Full record

ArticleBritish journal of pharmacology2022

Inhibition of sodium conductance by cannabigerol contributes to a reduction of dorsal root ganglion neuron excitability.

Mohammad-Reza Ghovanloo, Mark Estacion, Grant P Higerd-Rusli, Peng Zhao, Sulayman Dib-Hajj, Stephen G Waxman

Open access · bronzeAbstract read
In one paragraph

Article in British journal of pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 31 citations in OpenAlex.

  1. The psychoactive cannabinoid THC inhibits peripheral nociceptors by targeting NaNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
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  3. Review
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  7. Nav1.8, an analgesic target for nonpsychotomimetic phytocannabinoids.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Pathology of pain and its implications for therapeutic interventions.Signal transduction and targeted therapy · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Conserved but not critical: Trafficking and function of NaFrontiers in molecular neuroscience · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mohammad-Reza GhovanlooDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-2171-0744
Mark EstacionDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-7271-1165
Grant P Higerd-RusliDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0001-8288-576X
Peng ZhaoDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-5527-3044
Sulayman Dib-HajjDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-4137-1655
Stephen G WaxmanDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0001-5718-7177
Yale University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
The Role of Sodium Channel Nav1.7 in Osteoarthritis - Resubmission - 1R01AR078035 · NIAMS · YALE UNIVERSITY · PI Chuanju Liu, Stephen Waxman · 2022 to 2026
$2.8M
Mechanisms and specificity of sodium channel trafficking: Developing a novel analgesic strategyF31NS122417 · NINDS · YALE UNIVERSITY · PI HIGERD, GRANT PHILIP · 2021 to 2022
$62k
Sodium Channel Nav1.6 in Chemotherapy-Induced PainI01RX003621 · VA · VA CONNECTICUT HEALTHCARE SYSTEM · PI DIB-HAJJ, SULAYMAN D · 2022 to 2025
–
Center for Restoration of Nervous System FunctionI50RX002999 · VA · VA CONNECTICUT HEALTHCARE SYSTEM · PI Sulayman D Dib-Hajj, Stephen Waxman · 2018 to 2026
–
BLRD VA I01 BX000605BLRD VA I01 BX004899NIAMS NIH HHS R01 AR078035NIGMS NIH HHS T32 GM007205NINDS NIH HHS F31 NS122417RRD VA I01 RX000395RRD VA I01 RX000477RRD VA I01 RX003201RRD VA I01 RX003621RRD VA I21 RX001720RRD VA I50 RX002999
6 · The paper itself

Abstract

background and purposeCannabigerol (CBG), a non-psychotropic phytocannabinoid and a precursor of ∆ EXPERIMENTAL APPROACH: To determine the effects of CBG on Na KEY

resultsCBG is a ~10-fold state-dependent Na CONCLUSIONS AND IMPLICATIONS: Inhibition of Na

Indexed as

Ganglia, SpinalSodiumCannabinoidsNeuronsSodium Channel BlockerscannabigerolCannabinoidsSodiumSodium Channel Blockerscannabigeroldorsal root ganglionpainpharmacologyvoltage-gated sodium channel

Identifiers

PMID35297036
PMCPMC13012276
OpenAlexW4220689002

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.