ArticleEcotoxicology (London, England)2022
Effects of Cu, Zn and their mixtures on bioaccumulation and antioxidant enzyme activities in Galleria mellonella L. (Lepidoptera: Pyralidae).
Article in Ecotoxicology (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- Bioaccumulation of Metals in Brain, Eye, Skeleton, and Skin Tissues of Wastewater-Fed Fish: A Case Study in Turkey.Toxics · 2026Article
- Investigation of the Effects of Silicon Dioxide Nanoparticles and Environmental Contaminants on Immunocytotoxic and Antioxidant Defense Systems in Model Organism Galleria mellonella L.Biological trace element research · 2025Article
- Insects as Sentinels of Oxidative Stress Induced by Environmental Contaminants: Biomarkers and Analytical Approaches.Toxics · 2025Review
- Review
- Exploring the Antioxidant Potential ofNutrients · 2023Article
- Galleria mellonella as a Simple Yet Reliable In Vivo Model for Nanotoxicology: Techniques and Applications.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of Cu, Zn and their mixture on bioaccumulation and antioxidant enzyme activities of midgut and fat body of Galleria mellonella larvae were investigated. Exposure to mixtures of both metals showed a synergistic effect and the accumulation levels were increased in both tissues. When the metals were exposed separately the concentration of Zn increased in both tissues, whereas the concentration of Cu increased in midgut and decreased in fat body. Also, it was determined that, oxidative stress occurred in the midgut and fat body when G. mellonella larvae were fed singly and in a mixture with different concentrations of Cu and Zn. In addition, significant changes were observed in antioxidant and detoxification enzyme activities, which are an indicator of oxidative stress. Larvae of G. mellonella showed immune responses similar to vertebrates, and could be used as bioindicator species due to being grown easily in the laboratory and reduced research costs Understanding the detoxification mechanism in insects is an important parameter for future ecotoxicological studies on the genotoxic, cytotoxic and physiological effects that different environmental pollutants such as heavy metals can cause.
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Registered trials
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