ArticleNature2022
A single-cell atlas of human and mouse white adipose tissue.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 569 papers.
0numbers the graph read from it
0cells of the map it votes in
569citing papers in PubMed
110.9field-weighted citation impact, top 1% of its field
What it found
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Who cites it
569 citing papers in PubMed, 771 citations in OpenAlex.
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- Review
- Multi-omics profiling reveals molecular features of visceral adiposity in autonomous cortisol secretion.iScience · 2026Article
- From Adipose Immune Homeostasis to Atherosclerosis and Hepatic Steatosis: The Adipocyte MHCII-Treg Axis in Obesity.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Effects of 6-OHDA-Mediated Chemical Denervation of Sympathetic Axons in Inguinal Subcutaneous White Adipose Tissue.Diabetes, obesity & metabolism · 2026Article
- A futile NaNature metabolism · 2026Article
- Human Genetics of Adipose Dysfunction: Genomic Mechanisms and Therapeutic Opportunities in Cardiometabolic Disease.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- The Adipovascular Unit in Lipedema: A Framework for Regional Adipose Tissue Dysregulation.Cells · 2026Review
- An RNA thermogenic therapy to preserve lean mass and enhance metabolic health during GLP-1 weight loss.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genotype-driven variations in lncRNA expression underlie predisposition to high-grade serous ovarian cancer.Journal of advanced research · 2026Article
- Molecular Mechanisms Underlying the Comorbidity of Type 2 Diabetes Mellitus and Coronary Artery Disease: from Insulin Resistance and Inflammation to Endothelial Dysfunction and Therapeutic Implications.Cardiovascular drugs and therapy · 2026Review
- Adipose tissue depots and blood pressure regulation: mechanisms, biomarkers, and targets beyond obesity.American journal of hypertension · 2026Review
- Tagln1-Cre-driven Ercc1 deficiency reveals sex-specific effects on adipose tissue in mice.Endocrinology · 2026Article
- Cardiovascular-kidney-metabolic syndrome as a mitochondrial systems disorder.Nature reviews. Nephrology · 2026Review
- Shared non-HLA genetic architecture across diverse ancestries links insulin secretion and resistance to type 1 diabetes.Diabetologia · 2026Article
- Folic acid polyglutamylation triggers MAP2K5 signaling to induce adipocyte lipid catabolism.bioRxiv : the preprint server for biology · 2026Article
- Transient activation of ciliary CCR2 signaling promotes the initiation of adipogenesis.Nature communications · 2026Article
- Systems genetics approaches model the heritable architecture of polyendocrine metabolic ovarian syndrome.The Journal of clinical investigation · 2026Article
- Scalable context-dependent single-cell eQTL mapping reveals disease-relevant regulatory variation beyond static models.medRxiv : the preprint server for health sciences · 2026Article
509 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
38 authors at 6 institutions in 3 countries.
Margo P EmontDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9873-2784
Christopher JacobsDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6034-1873
Adam L EsseneDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Deepti PantDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Danielle TenenDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Georgia ColleluoriDepartment of Experimental and Clinical Medicine, Center of Obesity, Marche Polytechnic University, Ancona, Italy.ORCID http://orcid.org/0000-0002-4908-9873
Angelica Di VincenzoDepartment of Experimental and Clinical Medicine, Center of Obesity, Marche Polytechnic University, Ancona, Italy.
Anja M JørgensenNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Hesam DashtiBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Adam StefekBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Elizabeth McGonagleBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-9708-9272
Sophie StrobelBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Samantha LaberBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Saaket AgrawalBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Gregory P WestcottDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4321-3992
Amrita KarDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Molly L VereggeDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Anton GulkoDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Harini SrinivasanDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Zachary KramerDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Eleanna De FilippisDivision of Endocrinology, Diabetes and Metabolism, Mayo Clinic Scottsdale, AZ, USA.ORCID http://orcid.org/0000-0002-5622-6709
Erin MerkelDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Jennifer DucieDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Christopher G BoydDepartment of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA.
William GourashDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Anita CourcoulasDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Samuel J LinDivision of Plastic Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Bernard T LeeDivision of Plastic Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Donald MorrisDivision of Plastic Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Adam TobiasDivision of Plastic Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Amit V KheraBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Melina ClaussnitzerBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Tune H PersNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-0207-4831
Antonio GiordanoDepartment of Experimental and Clinical Medicine, Center of Obesity, Marche Polytechnic University, Ancona, Italy.
Orr AshenbergKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Aviv RegevKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Linus T TsaiDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0134-6949
Evan D RosenDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA. erosen@bidmc.harvard.edu.ORCID http://orcid.org/0000-0003-4603-708X
Broad Institute · USBeth Israel Deaconess Medical Center · USMarche Polytechnic University · ITUniversity of Copenhagen · DKUniversity of Pittsburgh Medical Center · USMayo Clinic in Arizona · US
Funding
Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FLOREZ, JOSE CARLOS · 2000 to 2019
$31.4MTransgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI LOWELL, BRADFORD B · 1992 to 2021
$25.0MInvestigating Human Adipocyte HeterogeneityRC2DK116691 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Orr Ashenberg, Noel P Burtt · 2018 to 2026
$17.8MBridging the gap between type 2 diabetes GWAS and therapeutic targetsUM1DK126185 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CLAUSSNITZER, MELINA C, GLOYN, ANNA LOUISE · 2020 to 2024
$9.5MINTEGRATED ENDOCRINE &METABOLIC RESEARCH TRAININGT32DK007516 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BARBARA B. KAHN · 1986 to 2026
$6.8MEnabling improved applicability and transferability of polygenic scores across populationsU01HG011719 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI Alicia Martin · 2021 to 2026
$5.5MTranscriptional Mechanisms of Human Insulin ResistanceR01DK102173 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ROSEN, EVAN D · 2015 to 2022
$4.4MEpigenomics of Human Insulin ResistanceR01DK087092 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ROSEN, EVAN D · 2009 to 2013
$3.3MPolygenic prediction of common, complex diseasesK08HG010155 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI KHERA, AMIT VIKRAM · 2018 to 2021
$1.1MInvestigating the Regulation of IRF4 in AdipocytesF32DK124914 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI EMONT, MARGO PREMINGER · 2020 to 2021
$131kNHGRI NIH HHS K08 HG010155NHGRI NIH HHS U01 HG011719NIDDK NIH HHS F32 DK124914NIDDK NIH HHS P30 DK046200NIDDK NIH HHS P30 DK057521NIDDK NIH HHS R01 DK087092NIDDK NIH HHS R01 DK102173NIDDK NIH HHS RC2 DK116691NIDDK NIH HHS T32 DK007516NIDDK NIH HHS UM1 DK126185
Abstract
White adipose tissue, once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of biological processes including energy homeostasis, glucose and lipid handling, blood pressure control and host defence
Indexed as
Adipose Tissue, WhiteAtlases as TopicDiabetes Mellitus, Type 2Insulin ResistanceMetabolic DiseasesAdipose TissueAdiposityAnimalsHumansMiceObesity
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.