Evidence map›Paper›PMID 35296861›Full record

ArticleNature2022

Reproducible brain-wide association studies require thousands of individuals.

Scott Marek, Brenden Tervo-Clemmens, Finnegan J Calabro, David F Montez, Benjamin P Kay, Alexander S Hatoum, Meghan Rose Donohue, William Foran, Ryland L Miller, Timothy J Hendrickson and 35 more

Erratum issuedAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1,259 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,259citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,259 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. ΔBiological psychiatry. Cognitive neuroscience and neuroimaging · 2026
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  7. Trial
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. The neuroanatomy of depression: weak but replicable effects in 4021 individuals from three clinical cohorts.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  17. Big data and psychiatry: advances, constraints and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026
    Article
  18. Article
  19. Article
  20. Article

1,199 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

45 authors.

Scott Marek *Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA. smarek@wustl.edu.ORCID http://orcid.org/0000-0003-0032-9052
Brenden Tervo-Clemmens *Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. btervo-clemmens@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-9557-1126
Finnegan J CalabroDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-8092-3942
David F MontezDepartment of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Benjamin P KayDepartment of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Alexander S HatoumDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Meghan Rose DonohueDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
William ForanDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Ryland L MillerDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Timothy J HendricksonUniversity of Minnesota Informatics Institute, University of Minnesota, Minneapolis, MN, USA.
Stephen M MaloneDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Sridhar KandalaDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Eric FeczkoMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA.
Oscar Miranda-DominguezMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA.
Alice M GrahamDepartment of Psychiatry, Oregon Health and Science University, Portland, OR, USA.
Eric A EarlMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-5512-0083
Anders J PerroneMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA.
Michaela CordovaDepartment of Psychiatry, Oregon Health and Science University, Portland, OR, USA.
Olivia DoyleDepartment of Psychiatry, Oregon Health and Science University, Portland, OR, USA.ORCID http://orcid.org/0000-0003-3957-2949
Lucille A MooreDepartment of Psychiatry, Oregon Health and Science University, Portland, OR, USA.ORCID http://orcid.org/0000-0002-7665-2713
Gregory M ConanMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA.
Johnny UriarteDepartment of Psychiatry, Oregon Health and Science University, Portland, OR, USA.
Kathy SniderDepartment of Psychiatry, Oregon Health and Science University, Portland, OR, USA.
Benjamin J LynchMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-7310-2022
James C WilgenbuschMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA.
Thomas PengoUniversity of Minnesota Informatics Institute, University of Minnesota, Minneapolis, MN, USA.
Angela TamDepartment of Electrical and Computer Engineering, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0001-6752-5707
Jianzhong ChenDepartment of Electrical and Computer Engineering, National University of Singapore, Singapore, Singapore.
Dillan J NewboldDepartment of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Annie ZhengDepartment of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Nicole A SeiderDepartment of Neurology, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0003-1511-1515
Andrew N VanDepartment of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Athanasia MetokiDepartment of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Roselyne J ChauvinDepartment of Neurology, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0001-5786-4705
Timothy O LaumannDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Deanna J GreeneDepartment of Cognitive Science, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-0739-7771
Steven E PetersenDepartment of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Hugh GaravanDepartment of Psychiatry, University of Vermont, Burlington, VT, USA.
Wesley K ThompsonDivision of Biostatistics, University of California San Diego, La Jolla, CA, USA.
Thomas E NicholsOxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-4516-5103
B T Thomas YeoDepartment of Electrical and Computer Engineering, National University of Singapore, Singapore, Singapore.
Deanna M BarchDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0003-1693-8506
Beatriz LunaDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
Damien A FairMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA. faird@umn.edu.ORCID http://orcid.org/0000-0001-8602-393X
Nico U F DosenbachDepartment of Neurology, Washington University School of Medicine, St Louis, MO, USA. ndosenbach@wustl.edu.ORCID http://orcid.org/0000-0002-6876-7078

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7M
ABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5M
Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
Adolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5M
ABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7M
Prospective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2M
ABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7M
ABCD-USA Consortium: Research ProjectU01DA041106 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mary M Heitzeg, Chandra Sekhar Sripada · 2015 to 2026
$24.9M
FIU-ABCD: Pathways and Mechanisms to Addiction in the Latino Youth of South FloridaU01DA041156 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI Raul Gonzalez, Angela R Laird · 2015 to 2026
$22.8M
ABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3M
ABCD-USA: NYC Research ProjectU01DA041174 · NIDA · YALE UNIVERSITY · PI Arielle Ryan Baskin-Sommers, Betty J Casey · 2015 to 2026
$19.7M
Medical Research Council MC_PC_17228Medical Research Council MC_QA137853NCATS NIH HHS UL1 TR002345NIAAA NIH HHS R21 AA026919NICHD NIH HHS P50 HD103525NIDA NIH HHS K12 DA043490NIDA NIH HHS T32 DA007261NIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041025NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041093NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U01 DA050988NIDA NIH HHS U01 DA050989NIDA NIH HHS U01 DA051038NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147NIMH NIH HHS K01 MH104592NIMH NIH HHS K23 MH125023NIMH NIH HHS K99 MH121518NIMH NIH HHS R00 MH121518NIMH NIH HHS R01 MH096773NIMH NIH HHS R01 MH115357NIMH NIH HHS R25 MH112473NIMH NIH HHS R44 MH121276NIMH NIH HHS R44 MH122066NIMH NIH HHS R44 MH124567NIMH NIH HHS T32 MH100019NIMH NIH HHS U54 MH091657NINDS NIH HHS F31 NS110332NINDS NIH HHS K23 NS088590NINDS NIH HHS K23 NS123345NINDS NIH HHS P50 NS022343NINDS NIH HHS R25 NS090978NINDS NIH HHS T32 NS115672NINDS NIH HHS UE5 NS090978Wellcome Trust
6 · The paper itself

Abstract

Magnetic resonance imaging (MRI) has transformed our understanding of the human brain through well-replicated mapping of abilities to specific structures (for example, lesion studies) and functions

Indexed as

BrainBrain MappingMagnetic Resonance ImagingCognitionDatasets as TopicHumansNeuroimagingPhenotypeReproducibility of Results

Identifiers

PMID35296861
PMCPMC8991999

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.