Evidence map›Paper›PMID 35296859›Full record

ArticleNature2022

A multidimensional coding architecture of the vagal interoceptive system.

Qiancheng Zhao, Chuyue D Yu, Rui Wang, Qian J Xu, Rafael Dai Pra, Le Zhang, Rui B Chang

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers.

0numbers the graph read from it
0cells of the map it votes in
136citing papers in PubMed
23.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

136 citing papers in PubMed, 208 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Peripheral Neuropathy in Metabolic Stress.International journal of molecular sciences · 2026
    Review
  6. Vagal sensory neurons profusely innervate the mouse gall bladder.Autonomic neuroscience : basic & clinical · 2026
    Article
  7. Review
  8. The critical role of gut-brain signalling in eating behaviour and obesity.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. VipCell reports · 2026
    Article
  19. Review
  20. Article

76 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Qiancheng ZhaoDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.
Chuyue D YuDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.
Rui WangDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.
Qian J XuDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.
Rafael Dai PraDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-5282-0682
Le ZhangDepartment of Neurology, Yale University School of Medicine, New Haven, CT, USA. le.zhang@yale.edu.
Rui B ChangDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, USA. rui.chang@yale.edu.ORCID http://orcid.org/0000-0001-6953-2943
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Understanding the molecular and functional architecture of diverse body-brain pathwaysR01AT012041 · NCCIH · YALE UNIVERSITY · PI CHANG, RUI · 2022 to 2025
$3.0M
Understand the little brain on the heart: a molecular and functional dissection of the intrinsic cardiac nervous systemDP2HL151354 · NHLBI · YALE UNIVERSITY · PI CHANG, RUI · 2019 to 2019
$2.5M
A molecular and functional dissection of the vagal heart-to-brain physiological circuitsR01HL150449 · NHLBI · YALE UNIVERSITY · PI CHANG, RUI · 2020 to 2023
$1.7M
GLP1R neurons in the subfornical organ and integration of thirst and satiety cuesK01DK113047 · NIDDK · YALE UNIVERSITY · PI CHANG, RUI · 2017 to 2020
$619k
NCATS NIH HHS UL1 TR001863NCCIH NIH HHS R01 AT012041NHLBI NIH HHS DP2 HL151354NHLBI NIH HHS R01 HL150449NIDDK NIH HHS K01 DK113047
6 · The paper itself

Abstract

Interoception, the ability to timely and precisely sense changes inside the body, is critical for survival

Indexed as

PerceptionPsychophysiologyVagus NerveVomeronasal OrganAnimalsBrainCalciumMammalsMiceSensory Receptor CellsCalcium

Identifiers

PMID35296859
PMCPMC8967724
OpenAlexW4220742257

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.