ArticleNature2022
Human gut bacteria produce Τ
Open access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 363 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
363citing papers in PubMed, 1 pooled it
51.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
363 citing papers in PubMed, 1 synthesis or guideline pooled it, 522 citations in OpenAlex.
- A meta-analysis of the gut microbiome in inflammatory bowel disease patients identifies disease-associated small molecules.Cell host & microbe · 2025Pooled it
- Trial
- A 4-guanidinobutanoic acid-SLC36A1 axis drives a microbiota‒host feedback loop to regulate intestinal homeostasis.Gut microbes · 2026Article
- A bile acid-GPBAR1 network supports anti-inflammatory and anti-fibrotic benefits of probiotics in colitis.Gut microbes · 2026Article
- Sex differences in the gut microbiome and related metabolites: role in cardiometabolic disease.Gut microbes · 2026Review
- Dietary and nutritional strategies for reducing disease risk associated with antibiotic-induced dysbiosis.Gut microbes · 2026Review
- IgA deficiency reveals a microbiota-dependent pathway to gluten sensitivity.Gut microbes · 2026Article
- Article
- The cervicovaginal gut microbiota axis as a key determinant of systemic physiology.Gut microbes · 2026Review
- Bile salt hydrolase activity as a rational target for MASLD therapy.Gut microbes · 2026Article
- Lachnospiraceae in the Food-Gut Axis: A Critical Review of Dietary Modulation, Immune Regulation, and Translational Barriers.Comprehensive reviews in food science and food safety · 2026Review
- Eggerthella lenta: metabolism, pathogenesis and therapeutic implications.Nature reviews. Microbiology · 2026Review
- Hepatic control of immunometabolism: implications for the pathogenesis, diagnosis and treatment of rheumatic diseases.Nature reviews. Rheumatology · 2026Review
- Pleiotropic roles of microbial bile acid metabolism in intestinal health and diseases.Cell host & microbe · 2026Review
- Microbial cues and T cell immunity: deciphering their interactions in chronic liver disease.Experimental & molecular medicine · 2026Review
- Gut microbiota‑immune crosstalk in recurrent pregnancy loss: Mechanisms and therapeutic perspectives (Review).Molecular medicine reports · 2026Review
- A Dominant Probiotic from the Traditional Chinese Fermented Food Douzhier Exhibits Anti-Influenza Activity.Nutrients · 2026Article
- Article
- Bile acid metabolism and signaling in human and animal health: A One Health perspective.iMetaOmics · 2026Review
- Gut-derived hyodeoxycholate reprograms the spleen-eye immunometabolic axis to suppress autoimmune uveitis.Cell death and differentiation · 2026Article
303 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
21 authors at 7 institutions in 2 countries.
Donggi Paik *Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1031-0371
Lina Yao *Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1018-5646
Yancong ZhangBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-2768-2975
Sena BaeDepartment of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Gabriel D D'AgostinoDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Minghao ZhangTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Eunha KimDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7041-1727
Eric A FranzosaDepartment of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8798-7068
Julian Avila-PachecoBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-9388-3946
Jordan E BisanzDepartment of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-8649-1706
Christopher K RakowskiDepartment of Chemistry, Bucknell University, Lewisburg, PA, USA.
Hera VlamakisBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-1086-9191
Ramnik J XavierBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-5630-5167
Peter J TurnbaughDepartment of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-0888-2875
Randy S LongmanJill Roberts Center for IBD, Weill Cornell Medicine, New York, NY, USA.
Michael R KroutDepartment of Chemistry, Bucknell University, Lewisburg, PA, USA.
Clary B ClishBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8259-9245
Fraydoon RastinejadTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Curtis HuttenhowerBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1110-0096
Jun R HuhDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. jun_huh@hms.harvard.edu.ORCID http://orcid.org/0000-0002-1540-6244
A Sloan DevlinDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. sloan_devlin@hms.harvard.edu.ORCID http://orcid.org/0000-0001-5598-3751
Harvard University · USBroad Institute · USBucknell University · USUniversity of California, San Francisco · USUniversity of Oxford · GBBrigham and Women's Hospital · USCornell University · US
Funding
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3MSTRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JERROLD R. TURNER · 1986 to 2026
$32.4MROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Alessio Fasano · 1994 to 2026
$31.6MA comprehensive platform for novel therapy development from the microbiomeR24DK110499 · NIDDK · BROAD INSTITUTE, INC. · PI HUTTENHOWER, CURTIS · 2017 to 2021
$7.7MBacterial metabolites controlling Th17 cellsR01DK110559 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HUH, JUN R. · 2016 to 2024
$5.1MEmploying the gut microbiome to accelerate effective initiation of rheumatoid arthritis therapyR01AR074500 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Renuka Rajendra Nayak, Jose U. Scher · 2019 to 2026
$4.1MHuman microbiome metabolites in health and diseaseR35GM128618 · NIGMS · HARVARD MEDICAL SCHOOL · PI Abigail Sloan Devlin · 2018 to 2026
$4.1MPrinciples of Scientific Citizenship: Ethics, Communication, and Leadership for ScientistsT32GM095450 · NIGMS · HARVARD UNIVERSITY · PI WALKER, SUZANNE · 2011 to 2020
$3.5MCharacterizing the gut microbial ecosystem for diagnosis and therapy in IBDU54DE023798 · NIDCR · BROAD INSTITUTE, INC. · PI HUTTENHOWER, CURTIS, XAVIER, RAMNIK J · 2013 to 2014
$3.0MTL1A Regulation of Group 3 Innate Lymphoid Cells in ColitisR01DK120985 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI Randy S Longman · 2020 to 2026
$2.9MHost-Microbiota Interactions in Crohn's Disease-associated SpondyloarthritisR01DK114252 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI LONGMAN, RANDY S · 2018 to 2022
$1.9MDiet-microbe interactions modulating host energy balanceR00AI147165 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI BISANZ, JORDAN ADAM · 2021 to 2022
$498kNIAID NIH HHS K99 AI147165NIAID NIH HHS R00 AI147165NIAMS NIH HHS R01 AR074500NIDCR NIH HHS U54 DE023798NIDDK NIH HHS P30 DK034854NIDDK NIH HHS P30 DK040561NIDDK NIH HHS P30 DK043351NIDDK NIH HHS R01 DK110559NIDDK NIH HHS R01 DK114252NIDDK NIH HHS R01 DK120985NIDDK NIH HHS R24 DK110499NIGMS NIH HHS R35 GM128618NIGMS NIH HHS T32 GM095450Wellcome Trust 210664/Z/18/Z
Abstract
The microbiota modulates gut immune homeostasis. Bacteria influence the development and function of host immune cells, including T helper cells expressing interleukin-17A (T
Indexed as
BacteriaBile Acids and SaltsInflammatory Bowel DiseasesCell DifferentiationGastrointestinal TractHumansInterleukin-17Lithocholic AcidTh17 CellsBile Acids and SaltsIL17A protein, humanInterleukin-17Lithocholic Acid
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.