ArticleNature2022
A kinase-cGAS cascade to synthesize a therapeutic STING activator.
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In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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59citing papers in PubMed
–field-weighted citation impact
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Who cites it
59 citing papers in PubMed.
- Benzothiazole derivatives target oligoadenylate synthetase and enhance RSV vaccine efficacy as adjuvants.Bioactive materials · 2027Article
- Article
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- A Universal Nucleoside-to-Nucleoside-5'-Triphosphate Enzyme Cascade Driven by Polyphosphate.Angewandte Chemie (International ed. in English) · 2026Article
- Ganoderma lucidum spore powder enhances IFN-α-mediated antiviral capacity of COVID-19 vaccine boosters revealed by single-cell multi-omics sequencing.Journal of advanced research · 2026Article
- A neutrophil-tumor cascade-targeting Trojan horse for heterobifunctional prodrug delivery to enhance cGAS-STING cancer immunotherapy.Journal of nanobiotechnology · 2026Article
- Engineering Enantiocomplementary Protoglobins for Stereoconvergent Construction ofJournal of the American Chemical Society · 2026Article
- Nanotechnology-driven STING regulation for on-demand therapy.Acta pharmaceutica Sinica. B · 2026Review
- Betrixaban activates cGAS and ERVs to promote dual nucleic-sensing antiviral immunity.EMBO molecular medicine · 2026Article
- Transaminase and Norcoclaurine Synthase One-Pot Cascades Towards (1S)-Tetrahydroisoquinolines.Chembiochem : a European journal of chemical biology · 2026Article
- Biochemical Engineering Perspective on cGAS: From Enzyme Discovery to Potential Industrial Application.Chembiochem : a European journal of chemical biology · 2026Review
- Precision targeting of STING: Challenges, innovations, and clinical outlook for cancer therapy.Innovation (Cambridge (Mass.)) · 2026Review
- Enzymatic synthesis of key RNA therapeutic building blocks using simple phosphate donors.Nature communications · 2025Article
- Targeting pattern recognition receptors for cancer therapy: Mechanisms and strategies.Acta pharmaceutica Sinica. B · 2025Review
- Combining biocatalytic and radical retrosynthesis for efficient chemoenzymatic synthesis of natural products.Chemical Society reviews · 2025Review
- Selective Phosphorylation of Phenols and Benzenediols by the Kinase PsiK and Variants Thereof.Angewandte Chemie (International ed. in English) · 2025Article
- The cGAS-STING pathway: a dual regulator of immune response in cancer and therapeutic implications.Journal of translational medicine · 2025Review
- Biosynthesis of Biphenomycin-like Macrocyclic Peptides by Formation and Cross-Linking ofJournal of the American Chemical Society · 2025Article
- An Update: Enzymatic Synthesis for Industrial Applications.Angewandte Chemie (International ed. in English) · 2025Review
- Hydrophilic/Omniphobic Droplet Arrays for High-throughput and Quantitative Enzymology.Analytical chemistry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
61 authors.
John A McIntoshProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA. john.mcintosh1@merck.com.ORCID http://orcid.org/0000-0002-9487-490X
Zhijian LiuProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA. liuquani@gmail.com.
Brian M AndresenDiscovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA. brian.m.andresen@gmail.com.ORCID http://orcid.org/0000-0002-9645-3359
Nastaran Salehi MarzijaraniProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.ORCID http://orcid.org/0000-0001-8940-4674
Jeffrey C MooreProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.ORCID http://orcid.org/0000-0002-9807-6315
Nicholas M MarshallProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Margie Borra-GarskeCodexis, Inc., Redwood City, CA, USA.
Jennifer V ObligacionProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Patrick S FierProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Feng PengProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Jacob H ForstaterProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Matthew S WinstonProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Chihui AnProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Wonsuk ChangDiscovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA.
Jongwon LimDiscovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA.
Mark A HuffmanProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Steven P MillerProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.ORCID http://orcid.org/0000-0001-8615-274X
Fuh-Rong TsayAnalytical Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Michael D AltmanDiscovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA.
Charles A LesburgDiscovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA.ORCID http://orcid.org/0000-0001-7245-7331
Dietrich SteinhuebelProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
B Wesley TrotterDiscovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA.ORCID http://orcid.org/0000-0002-6780-0358
Jared N CummingDiscovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA.
Alan NorthrupDiscovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA.
Xiaodong BuAnalytical Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Benjamin F MannAnalytical Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Mirlinda BibaAnalytical Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Kaori HiragaProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Grant S MurphyProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.ORCID http://orcid.org/0000-0003-0388-0309
Joshua N KolevProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Amanda MakarewiczProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Weilan PanProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Iman FarasatProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Rachel S BadeProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.ORCID http://orcid.org/0000-0002-5384-9687
Kevin StoneProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Da DuanCodexis, Inc., Redwood City, CA, USA.
Oscar AlvizoCodexis, Inc., Redwood City, CA, USA.
Donovan AdpressaDiscovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA.
Erik GuetschowAnalytical Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Erik HoytAnalytical Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Erik L RegaladoProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.ORCID http://orcid.org/0000-0002-7352-6391
Steve CastroAnalytical Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Nelo RiveraAnalytical Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Joseph P SmithAnalytical Research & Development, Merck & Co., Inc., Rahway, NJ, USA.ORCID http://orcid.org/0000-0002-0062-2534
Fengqiang WangAnalytical Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Alejandro CrespoProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Deeptak VermaProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.ORCID http://orcid.org/0000-0003-0740-0624
Stephanus AxnandaAnalytical Research & Development, Merck & Co., Inc., Rahway, NJ, USA.ORCID http://orcid.org/0000-0002-7239-9220
Zachary E X DanceAnalytical Research & Development, Merck & Co., Inc., Rahway, NJ, USA.ORCID http://orcid.org/0000-0003-1807-7930
Paul N DevineProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
David TschaenProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Keith A CanadaProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Paul G BulgerProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Benjamin D SherryProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Matthew D TruppoProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Rebecca T RuckProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.ORCID http://orcid.org/0000-0001-9980-9675
Louis-Charles CampeauProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.ORCID http://orcid.org/0000-0002-2373-802X
David Jonathan BennettDiscovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA.ORCID http://orcid.org/0000-0003-0163-7479
Guy R HumphreyProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Kevin R CamposProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Matthew L MaddessProcess Research & Development, Merck & Co., Inc., Rahway, NJ, USA.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The introduction of molecular complexity in an atom- and step-efficient manner remains an outstanding goal in modern synthetic chemistry. Artificial biosynthetic pathways are uniquely able to address this challenge by using enzymes to carry out multiple synthetic steps simultaneously or in a one-pot sequence
Indexed as
GuanosineNucleotidyltransferasesAdenosineAnimalsInterferonsMembrane ProteinsSignal TransductionAdenosineGuanosineInterferonsMembrane ProteinsNucleotidyltransferases
Identifiers
PMID
35296845What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.