ArticleScientific reports2022
Association of adverse birth outcomes with in vitro fertilization after controlling infertility factors based on a singleton live birth cohort.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Association between endometriosis and adverse reproductive and perinatal outcomes in women undergoing assisted reproductive technology: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Ultra-low oxygen tension duringbioRxiv : the preprint server for biology · 2026Article
- IVF and pregnancy outcomes: the triumphs, challenges, and unanswered questions.Journal of ovarian research · 2025Review
- The Association Between Infertility Treatment and Birth Outcomes for Nulliparous Persons Who Gave Birth 35 Years and Older: Findings from 2022 National Vital Statistics System Natality Data.Maternal and child health journal · 2025Article
- Single-centre comparative study of in vitro fertilisation and naturally conceived babies in Indonesia.BMJ paediatrics open · 2025Article
- Risk factors for neonatal admission from the beginning of pregnancy in Northeast Spain.Journal of paediatrics and child health · 2025Observational
- Changes in adverse obstetrical and neonatal outcomes over time in American women with polycystic ovary syndrome: an 11-year study of a population database.Archives of gynecology and obstetrics · 2024Article
- Which transfer day results in the highest live birth rate for PCOS patients undergoing in vitro fertilization?BMC pregnancy and childbirth · 2023Article
- Long-Term Effects of ART on the Health of the Offspring.International journal of molecular sciences · 2023Review
- Secular trends of low birth weight, preterm birth, and small for gestational age in Shanghai from 2004 to 2020: an age-period-cohort analysis.BMC pregnancy and childbirth · 2023Article
- The influence of the increasing use of assisted reproduction technologies on the recent growth in fertility in Czechia.Scientific reports · 2023Article
- Eclampsia,Translational pediatrics · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infants conceived with in vitro fertilization (IVF) are exposed to underlying infertility and the IVF process. High risks of adverse birth outcomes (ABOs) were observed among these infants, including preterm birth, low birth weight, macrosomia, being large/small for gestational age (LGA/SGA). It is unclear whether the specific etiology of the rise of ABOs among IVF infants is IVF technology itself or underlying infertility. A total of 9,480 singletons conceived with IVF and 1,952,419 singletons from the general population were obtained in this study. Multivariable logistic regression model was used to assess variations in risk of ABOs according to causes of infertility. Poisson distributions were applied to calculate standardized risk ratios of IVF infants vs. general population after controlling the causes of infertility. Higher risk of preterm birth and low birth weight were observed among parents with polycystic ovary syndrome, endometriosis, uterine and semen abnormalities. Compared to the general population, after excluding the influence of infertility causes, singletons conceived with IVF were at higher risk of macrosomia (SRR = 1.28, 95% CI 1.14-1.44) and LGA (SRR = 1.25, 95% CI 1.15-1.35). The higher risk of ABOs in IVF was driven by both IVF treatments and infertility, which is important for improving IVF treatments and the managing pregnancies and child development.
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