ArticleCommunications biology2022
Sex and strategy effects on brain activation during a 3D-navigation task.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Preference for directional responding in a virtual Morris water task is associated with increased precuneus activation in adolescent humans.Behavioural brain research · 2026Article
- Knowledge, attitudes and practices regarding perioperative enhanced recovery after surgery in video-assisted thoracoscopic lobectomy among healthcare professionals.Scientific reports · 2025Article
- The Role of Temporal Order in Egocentric and Allocentric Spatial Representations.Journal of clinical medicine · 2023Article
- Hormonal contraceptive exposure relates to changes in resting state functional connectivity of anterior cingulate cortex and amygdala.Frontiers in endocrinology · 2023Article
- Sex and strategy effects on brain activation during a 3D-navigation task.Communications biology · 2022Article
- Duration of oral contraceptive use relates to cognitive performance and brain activation in current and past users.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Sex differences in navigation have often been attributed to the use of different navigation strategies in men and women. However, no study so far has investigated sex differences in the brain networks supporting different navigation strategies. To address this issue, we employed a 3D-navigation task during functional MRI in 36 men and 36 women, all scanned thrice, and modeled navigation strategies by instructions requiring an allocentric vs. egocentric reference frame on the one hand, as well as landmark-based vs. Euclidian strategies on the other hand. We found distinct brain networks supporting different perspectives/strategies. Men showed stronger activation of frontal areas, whereas women showed stronger activation of posterior brain regions. The left inferior frontal gyrus was more strongly recruited during landmark-based navigation in men. The hippocampus showed stronger connectivity with left-lateralized frontal areas in women and stronger connectivity with superior parietal areas in men. We discuss these findings in the light of a stronger recruitment of verbal networks supporting a more verbal strategy in women compared to a stronger recruitment of spatial networks supporting a more spatial strategy use in men. In summary, this study provides evidence that different navigation strategies activate different brain areas in men and women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.