Evidence map›Paper›PMID 35296791›Full record

Trial reportInternational journal of obesity (2005)2022

Preconception lifestyle intervention in women with obesity and echocardiographic indices of cardiovascular health in their children.

Tamara den Harink, Nico A Blom, Reinoud J B J Gemke, Henk Groen, Annemieke Hoek, Ben W J Mol, Rebecca C Painter, Irene M Kuipers, Tessa J Roseboom, Arend W van Deutekom

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in International journal of obesity (2005), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tamara den HarinkDepartment Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands. t.denharink@amsterdamumc.nl.ORCID http://orcid.org/0000-0001-7365-0619
Nico A BlomDepartment of Pediatric Cardiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Reinoud J B J GemkeDepartment of Pediatrics, Emma Children's Hospital Amsterdam UMC, Amsterdam, Amsterdam, the Netherlands.
Henk GroenDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Annemieke HoekDepartment of Obstetrics and Gynecology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Ben W J MolDepartment of Obstetrics and Gynecology, Monash University, Clayton, Victoria, Australia.
Rebecca C PainterDepartment of Obstetrics and Gynecology, Amsterdam UMC, Amsterdam Reproduction and Development, University of Amsterdam, Amsterdam, the Netherlands.
Irene M KuipersDepartment of Pediatric Cardiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Tessa J RoseboomDepartment Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Arend W van DeutekomDepartment Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImproving maternal lifestyle before conception may prevent the adverse effects of maternal obesity on their children's future cardiovascular disease (CVD) risk. In the current study, we examined whether a preconception lifestyle intervention in women with obesity could alter echocardiographic indices of cardiovascular health in their children.

methodsSix years after a randomized controlled trial comparing the effects of a 6-month preconception lifestyle intervention in women with obesity and infertility prior to fertility care to prompt fertility care, 315 of the 341 children conceived within 24 months after randomization were eligible for this study. The intervention was aimed at weight loss (≥5% or until BMI < 29 kg/m

resultsSixty children (32 girls, 53%) were included, mean age 6.5 years (SD 1.09). Twenty-four children (40%) were born to mothers in the intervention group. Children of mothers from the intervention group had a lower end-diastolic interventricular septum thickness (-0.88 Z-score, 95%CI -1.18 to -0.58), a lower left ventricle mass index (-8.56 g/m

conclusionsChildren of women with obesity, who underwent a preconception lifestyle intervention, had improved cardiac structure and function; a thinner interventricular septum, lower left ventricle mass, and improved systolic and diastolic tissue Doppler velocities. Despite its high attrition rates, our study provides the first experimental human evidence suggesting that preconception lifestyle interventions may present a method of reducing CVD risk in the next generation. CLINICAL

trial registrationLIFEstyle study: Netherlands Trial Register: NTR1530 ( https://www.trialregister.nl/trial/1461 ). This follow-up study was approved by the medical ethics committee of the University Medical Centre Groningen (METC code: 2008/284).

Indexed as

Cardiovascular DiseasesLife StyleBody Mass IndexChildEchocardiographyFemaleFollow-Up StudiesHumansObesityPregnancy

Identifiers

PMID35296791

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.