Evidence map›Paper›PMID 35296685›Full record

ArticleScientific reports2022

Tumor cell identification and classification in esophageal adenocarcinoma specimens by hyperspectral imaging.

Marianne Maktabi, Yannis Wichmann, Hannes Köhler, Henning Ahle, Dietmar Lorenz, Michael Bange, Susanne Braun, Ines Gockel, Claire Chalopin, René Thieme

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Clinical applications of hyperspectral imaging in gastroenterology and hepatology: A systematic review.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Pooled it
  3. Article
  4. Classification of esophageal cancer by using hyperspectral data.International journal of computer assisted radiology and surgery · 2026
    Article
  5. Article
  6. An automatic processing framework for hyperspectral histologic images and benchmark dataset.Proceedings of SPIE--the International Society for Optical Engineering · 2025
    Article
  7. Precision Imaging for Early Detection of Esophageal Cancer.Bioengineering (Basel, Switzerland) · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
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  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Marianne Maktabi *Innovation Center Computer Assisted Surgery (ICCAS), Leipzig University, Leipzig, Germany.
Yannis Wichmann *Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany.
Hannes KöhlerInnovation Center Computer Assisted Surgery (ICCAS), Leipzig University, Leipzig, Germany.
Henning AhleDepartment of General and Visceral Surgery, Sana Clinic Offenbach GmbH, Offenbach, Germany.
Dietmar LorenzDepartment of General, Visceral and Thoracic Surgery, Municipal Hospital of Darmstadt GmbH, Darmstadt, Germany.
Michael BangeInstitute of Pathology, Sana Clinic Offenbach GmbH, Offenbach, Germany.
Susanne BraunInstitute of Pathology, Sana Clinic Offenbach GmbH, Offenbach, Germany.
Ines GockelDepartment of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany.
Claire ChalopinInnovation Center Computer Assisted Surgery (ICCAS), Leipzig University, Leipzig, Germany.
René ThiemeDepartment of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany. rene.thieme@medizin.uni-leipzig.de.
Leipzig University · DESana Klinikum Offenbach · DEUniversity Hospital Leipzig · DEKlinikum Darmstadt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Esophageal cancer is the sixth leading cause of cancer-related death worldwide. Histopathological confirmation is a key step in tumor diagnosis. Therefore, simplification in decision-making by discrimination between malignant and non-malignant cells of histological specimens can be provided by combination of new imaging technology and artificial intelligence (AI). In this work, hyperspectral imaging (HSI) data from 95 patients were used to classify three different histopathological features (squamous epithelium cells, esophageal adenocarcinoma (EAC) cells, and tumor stroma cells), based on a multi-layer perceptron with two hidden layers. We achieved an accuracy of 78% for EAC and stroma cells, and 80% for squamous epithelium. HSI combined with machine learning algorithms is a promising and innovative technique, which allows image acquisition beyond Red-Green-Blue (RGB) images. Further method validation and standardization will be necessary, before automated tumor cell identification algorithms can be used in daily clinical practice.

Indexed as

AdenocarcinomaCarcinoma, Squamous CellEsophageal NeoplasmsArtificial IntelligenceHumansHyperspectral Imaging

Identifiers

PMID35296685
PMCPMC8927097
OpenAlexW4220955774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.