ArticleNature communications2022
CEP128 is involved in spermatogenesis in humans and mice.
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Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 60 citations in OpenAlex.
- WFS1 Deficiency Impairs PIAS4-Associated SUMOylation and Increases Ubiquitin-Mediated Spermatogenesis-Related Protein Degradation Leading to Testicular Male Infertility.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Human Sperm Centrosome: From Current Evidence to Future Perspectives-A Systematic Review.Life (Basel, Switzerland) · 2026Review
- Garin3 regulates sperm-oocyte fusion and male fertility.Cellular and molecular life sciences : CMLS · 2026Article
- Paternal Sertoli cell-derived extracellular vesicles transfer mtDNA and microRNA cargo to trigger germ cell oxidative stress and induce metabolic risks in offspring.Cell communication and signaling : CCS · 2026Article
- Male germ cell-specific deletion ofZoological research · 2026Article
- Dissecting the development of bovine testicular tissue using spatial transcriptomics.Journal of animal science and biotechnology · 2026Article
- The spermatozoon neck role in infertility and intracytoplasmic sperm injection outcomes.Journal of assisted reproduction and genetics · 2026Review
- Centriole Duplication, Maturation, and Transformation During Mammalian Spermatogenesis.Advances in experimental medicine and biology · 2026Review
- Targeting SKAP2 restores sperm motility and morphology through modulating mitochondrial organization and cytoskeletal remodeling.Signal transduction and targeted therapy · 2025Article
- Ploidy and Implantation Potential: Non-Invasive Small Non-Coding RNA-Based Health Assessment of Day 5 and 6 Blastocysts.International journal of molecular sciences · 2025Article
- Biallelic loss-of-function variants of DNAH7 cause male infertility associated with asthenozoospermia in humans.Human genetics · 2025Article
- Roles of human SPATA3 in cell proliferation and expression pattern ofMolecular medicine reports · 2025Article
- Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies.Andrology · 2025Review
- Function of manchette and intra-manchette transport in spermatogenesis and male fertility.Cell communication and signaling : CCS · 2025Review
- Loss of Cep135 causes oligoasthenoteratozoospermia and male infertility in mice.Cellular and molecular life sciences : CMLS · 2025Article
- Perfluorohexane Sulfonic Acid Disrupts the Immune Microenvironment for Spermatogenesis by Damaging the Structure of the Blood-Testis Barrier in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Genetic etiological spectrum of sperm morphological abnormalities.Journal of assisted reproduction and genetics · 2024Review
- A novel missense mutation of CCDC34 causes male infertility with oligoasthenoteratozoospermia in a consanguineous Pakistani family.Asian journal of andrology · 2024Article
- CEP112 coordinates translational regulation of essential fertility genes during spermiogenesis through phase separation in humans and mice.Nature communications · 2024Article
- Homozygous variant in DRC3 (LRRC48) gene causes asthenozoospermia and male infertility.Journal of human genetics · 2024Article
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Authors and funding
23 authors at 8 institutions in 1 country.
Xueguang Zhang *Department of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Lingbo Wang *Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Institute of Reproduction and Development, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 200011, China.
Yongyi Ma *Department of Gynecology and Obstetrics, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400000, China.
Yan Wang *Department of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Hongqian Liu *Department of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Mohan Liu *Department of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Lang Qin *Department of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Jinghong LiDepartment of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Chuan JiangDepartment of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Xiaojian ZhangSichuan Academy of Medical Sciences of Sichuan Provincial People's Hospital, Chengdu, 610041, China.
Xudong ShanWest China School of Basic Medical Sciences and Forensic Medicine, Chengdu, 610041, China.
Yuliang LiuChengdu Research Base of Giant Panda Breeding, Chengdu, 610041, China.
Jinsong LiCAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.ORCID http://orcid.org/0000-0003-3456-662X
Yaqian LiDepartment of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Rui ZhengDepartment of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Yongkang SunDepartment of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Jianfeng SunTeaching Hospital of Chengdu University of TCM, Chengdu, 610041, China.
Xiangyou LengDepartment of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Yan LiangResearch Core Facility of West China Hospital, Sichuan University, Chengdu, 610041, China.
Feng ZhangShanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Institute of Reproduction and Development, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 200011, China. zhangfeng@fudan.edu.cn.ORCID http://orcid.org/0000-0003-4556-8276
Xiaohui JiangDepartment of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, China. jxh424@126.com.ORCID http://orcid.org/0000-0001-5165-1442
Yihong YangDepartment of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, China. yyhpumc@foxmail.com.ORCID http://orcid.org/0000-0001-9138-7826
Ying ShenDepartment of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, China. yingcaishen01@163.com.ORCID http://orcid.org/0000-0002-6346-1002
Sichuan University · CNChinese Academy of Sciences · CNArmy Medical University · CNChengdu Research Base of Giant Panda Breeding · CNChengdu University · CNFudan University · CNObstetrics and Gynecology Hospital of Fudan University · CNWest China Medical Center of Sichuan University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Centrosomal proteins are necessary components of the centrosome, a conserved eukaryotic organelle essential to the reproductive process. However, few centrosomal proteins have been genetically linked to fertility. Herein we identify a homozygous missense variant of CEP128 (c.665 G > A [p.R222Q]) in two infertile males. Remarkably, male homozygous knock-in mice harboring the orthologous CEP128
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Infertility, MaleSpermatogenesisAnimalsHumansMaleMiceMice, KnockoutSpermatozoaSperm MotilityTestis
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