Evidence map›Paper›PMID 35296658›Full record

ArticleNature communications2022

Characterisation and induction of tissue-resident gamma delta T-cells to target hepatocellular carcinoma.

Nekisa Zakeri, Andrew Hall, Leo Swadling, Laura J Pallett, Nathalie M Schmidt, Mariana O Diniz, Stephanie Kucykowicz, Oliver E Amin, Amir Gander, Massimo Pinzani and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 117 citations in OpenAlex.

  1. γδ T cells and cancer.The Journal of clinical investigation · 2026
    Review
  2. γδ T cells in colorectal and liver cancer.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Harnessing Vδ1Frontiers in immunology · 2026
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Nekisa ZakeriDivision of Infection & Immunity, Institute of Immunity & Transplantation, University College London, London, UK.ORCID http://orcid.org/0000-0003-1167-1160
Andrew HallInstitute for Liver & Digestive Health, Royal Free London NHS Foundation Trust, London, UK.
Leo SwadlingDivision of Infection & Immunity, Institute of Immunity & Transplantation, University College London, London, UK.ORCID http://orcid.org/0000-0002-0537-6715
Laura J PallettDivision of Infection & Immunity, Institute of Immunity & Transplantation, University College London, London, UK.ORCID http://orcid.org/0000-0002-4161-9462
Nathalie M SchmidtDivision of Infection & Immunity, Institute of Immunity & Transplantation, University College London, London, UK.ORCID http://orcid.org/0000-0002-9841-8418
Mariana O DinizDivision of Infection & Immunity, Institute of Immunity & Transplantation, University College London, London, UK.
Stephanie KucykowiczDivision of Infection & Immunity, Institute of Immunity & Transplantation, University College London, London, UK.
Oliver E AminDivision of Infection & Immunity, Institute of Immunity & Transplantation, University College London, London, UK.ORCID http://orcid.org/0000-0003-3663-1253
Amir GanderDivision of Surgery, University College London, London, UK.
Massimo PinzaniInstitute for Liver & Digestive Health, Royal Free London NHS Foundation Trust, London, UK.
Brian R DavidsonDivision of Surgery, University College London, London, UK.
Alberto QuagliaDepartment of Cellular Pathology, Royal Free London NHS Foundation Trust and UCL Cancer Institute, London, UK.
Mala K MainiDivision of Infection & Immunity, Institute of Immunity & Transplantation, University College London, London, UK. m.maini@ucl.ac.uk.ORCID http://orcid.org/0000-0001-6384-1462
University College London · GBRoyal Free London NHS Foundation Trust · GBInstitute of Infection and Immunity · CA

Funding

Cancer Research UK 26603Cancer Research UK 26813Department of HealthMRF_ MRF-044-0001-RG-SWADLWellcome TrustWellcome Trust 175479Wellcome Trust 214191/Z/18/Z
6 · The paper itself

Abstract

Immunotherapy is now the standard of care for advanced hepatocellular carcinoma (HCC), yet many patients fail to respond. A major unmet goal is the boosting of T-cells with both strong HCC reactivity and the protective advantages of tissue-resident memory T-cells (T

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsHumansLymphocyte ActivationReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocyte SubsetsReceptors, Antigen, T-Cell, gamma-delta

Identifiers

PMID35296658
PMCPMC8927126
OpenAlexW4220656480

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.