ArticleTranslational psychiatry2022
Familial co-aggregation and shared heritability between depression, anxiety, obesity and substance use.
Article in Translational psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.Nature genetics · 2026Pooled it
- Genetic perspectives on the comorbidity of anxiety and mood disorders with cardiovascular disease.Nature cardiovascular research · 2026Review
- Intergenerational associations of depression and anxiety among adult mother-daughter dyads in China.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Comorbidity and Familial Aggregation of Mood Disorders and Cigarette Smoking in a Controlled Family Study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Article
- Adverse COVID-19 experiences and physical and psychological outcomes in patients with lung cancer.Palliative & supportive care · 2026Article
- Incident benzodiazepine and Z-drug use and subsequent risk of alcohol- and drug-related problems: A nationwide matched cohort study with co-twin comparison.Journal of psychopharmacology (Oxford, England) · 2026Article
- Associations between psychological distress and thyroid cancer, and the mediating role of lifestyle and metabolism: a cohort study from the UK Biobank.Frontiers in oncology · 2026Article
- Genetic nurture effects in depressive and anxiety disorders and symptoms, and in related traits.Molecular psychiatry · 2025Article
- Familial and genetic relationships of major depressive disorders and adiposity markers in the community.Translational psychiatry · 2025Article
- Early menopause in mothers and the risks of pre-diabetes and type 2 diabetes mellitus in female and male offspring: a population-based cohort study.Reproductive biology and endocrinology : RB&E · 2025Article
- Familial coaggregation and shared familiality of functional and internalizing disorders in the Lifelines cohort.Psychological medicine · 2025Article
- Brief Report: Intact Cognitive Functions in Children and Adolescents of Parents With Mood Disorders.Early intervention in psychiatry · 2025Article
- The saNeuroGut Initiative: Investigating the Gut Microbiome and Symptoms of Anxiety, Depression, and Posttraumatic Stress.Neuroimmunomodulation · 2025Article
- Mental healthcare utilisation among individuals with colorectal cancer: population-based cohort studies.BMJ oncology · 2025Article
- Familial confounding of internalising symptoms and obesity in adolescents and young adults; a co-twin analysis.International journal of obesity (2005) · 2024Article
- Causal links between sedentary behavior, physical activity, and psychiatric disorders: a Mendelian randomization study.Annals of general psychiatry · 2024Article
- Familial co-aggregation and shared genetics of cardiometabolic disorders and traits: data from the multi-generational Lifelines Cohort Study.Cardiovascular diabetology · 2023Article
- Sleep Apnea and Substance Use Disorders Associated with Co-Occurrence of Anxiety Disorder and Depression among U.S. Adults: Findings from the NSDUH 2008-2014.Brain sciences · 2023Article
- Stress-related exposures amplify the effects of genetic susceptibility on depression and anxiety.Translational psychiatry · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression, anxiety, obesity and substance use are heritable and often co-occur. However, the mechanisms underlying this co-occurrence are not fully understood. We estimated their familial aggregation and co-aggregation as well as heritabilities and genetic correlations to improve etiological understanding. Data came from the multi-generational population-based Lifelines Cohort Study (n = 162,439). Current depression and anxiety were determined using the MINI International Neuropsychiatric Interview. Smoking, alcohol and drug use were assessed by self-report questionnaires. Body mass index (BMI) and obesity were calculated by measured height and weight. Modified Cox proportional hazards models estimated recurrence risk ratios (λ
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.