Evidence map›Paper›PMID 35296622›Full record

ArticleInternal medicine (Tokyo, Japan)2022

AL-Kappa Primary Amyloidosis with Apolipoprotein A-IV Deposition.

Akira Ishimitsu, Akihiro Tojo, Jun Hirao, Shohei Yokoyama, Takehiro Ohira, Yoshiki Murayama, Toshihiko Ishimitsu, Dedong Kang, Kazuho Honda, Takashi Ehara and 2 more

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Akira IshimitsuDepartment of Nephrology & Hypertension, Dokkyo Medical University, Japan.
Akihiro TojoDepartment of Nephrology & Hypertension, Dokkyo Medical University, Japan.
Jun HiraoDepartment of Nephrology & Hypertension, Dokkyo Medical University, Japan.
Shohei YokoyamaDepartment of Nephrology & Hypertension, Dokkyo Medical University, Japan.
Takehiro OhiraDepartment of Nephrology & Hypertension, Dokkyo Medical University, Japan.
Yoshiki MurayamaDepartment of Nephrology & Hypertension, Dokkyo Medical University, Japan.
Toshihiko IshimitsuDepartment of Nephrology & Hypertension, Dokkyo Medical University, Japan.
Dedong KangDepartment of Anatomy, Showa University School of Medicine, Japan.
Kazuho HondaDepartment of Anatomy, Showa University School of Medicine, Japan.
Takashi EharaDepartment of Pathology, Shinshu University School of Medicine, Japan.
Kazuyuki IshidaDepartment of Diagnostic Pathology, Dokkyo Medical University, Japan.
Yoshihiko UedaDepartment of Pathology, Dokkyo Medical University Saitama Medical Center, Japan.
Dokkyo Medical University · JPShowa University · JPShinshu University · JPSocial Insurance Saitama Chuo Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 70-year-old woman with complaints of edema, general malaise, and hypotension was diagnosed with renal amyloidosis, and laser microdissection mass spectrometry revealed her amyloidosis to predominantly comprise the apolipoprotein A-IV type. The M-protein turned from negative to positive during the course, and a bone marrow biopsy showed smoldering myeloma. Treatment with bortezomib and dexamethasone failed to save her from heart failure six months after the onset. Western blotting of urine samples at the time of the renal biopsy showed that amyloid light-chain κ amyloidosis had been present since the onset. Unlike the myeloma, Congo red staining was positive in the plasma cells of the bone marrow.

Indexed as

AmyloidosisImmunoglobulin Light-chain AmyloidosisMultiple MyelomaAgedApolipoproteins AFemaleHumansapolipoprotein A-IVApolipoproteins AAL amyloidosisApolipoprotein A-IV amyloidosisCongo red stainingmyelomaplasma cell

Identifiers

PMID35296622
PMCPMC8987257
OpenAlexW4220789886

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.