Evidence map›Paper›PMID 35296537›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2022

Common and Divergent Features of T Cells from Blood, Gut, and Genital Tract of Antiretroviral Therapy-Treated HIV

Guorui Xie, Sara Moron-Lopez, David A Siegel, Kailin Yin, Anastasia Polos, Jennifer Cohen, Ruth M Greenblatt, Phyllis C Tien, Sulggi A Lee, Steven A Yukl and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Advances in HIV Research Using Mass Cytometry.Current HIV/AIDS reports · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Guorui XieGladstone Institute of Virology, San Francisco, CA.
Sara Moron-LopezDepartment of Medicine, University of California San Francisco, San Francisco, CA; and.ORCID 0000-0003-0800-9205
David A SiegelDepartment of Medicine, University of California San Francisco, San Francisco, CA; and.ORCID 0000-0001-7314-4556
Kailin YinGladstone Institute of Virology, San Francisco, CA.
Anastasia PolosDepartment of Medicine, University of California San Francisco, San Francisco, CA; and.
Jennifer CohenDepartment of Medicine, University of California San Francisco, San Francisco, CA; and.ORCID 0000-0001-7917-0915
Ruth M GreenblattDepartment of Medicine, University of California San Francisco, San Francisco, CA; and.
Phyllis C TienDepartment of Medicine, University of California San Francisco, San Francisco, CA; and.
Sulggi A LeeDepartment of Medicine, University of California San Francisco, San Francisco, CA; and.ORCID 0000-0003-1560-2250
Steven A YuklDepartment of Medicine, University of California San Francisco, San Francisco, CA; and.
Nadia R RoanGladstone Institute of Virology, San Francisco, CA; nadia.roan@gladstone.ucsf.edu.ORCID 0000-0002-5464-1976
San Francisco VA Medical Center · USGladstone Institutes · USUniversity of California, San Francisco · US

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 1988 to 2026
$93.6M
WOMEN'S INTERAGENCY HIV STUDY ORGANIZATION, MANAGEMENT AND COMMUNICATIONSU01AI034989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, GREENBLATT, RUTH MARTHA · 1993 to 2018
$65.6M
SF Bay Area MACS/WIHS Combined Cohort StudyU01HL146242 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bradley E Aouizerat, Jennifer Cohen Price · 2019 to 2026
$36.3M
Sex differences in the role of multi-omicsin HIV-associated carotid artery atherosclerosisU01HL146193 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Stephen J Gange, Elizabeth Topper · 2019 to 2026
$35.8M
HOPE - HIV Obstruction by Programmed EpigeneticsUM1AI164559 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI Lishomwa C Ndhlovu, Melanie Maria Ott · 2021 to 2026
$32.2M
Collaboratory of AIDS Researchers for Eradication (CARE)UM1AI164567 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2021 to 2026
$31.6M
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAISSE, CHRISTIAN · 2003 to 2019
$21.8M
The heterogeneous HIV expressing reservoir: dynamics, persistence mechanisms, tissue distribution, and contribution to reboundP01AI169606 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Steven A Yukl · 2022 to 2026
$9.3M
Project 3: Identifying plasma biomarkers predicting time to HIV rebound after treatment interruptionP01AI131374 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI ROAN, NADIA R · 2017 to 2021
$8.5M
Novel single genome approaches to determine the mechanisms of HIV latent infection in blood, gut, and lymph nodesR01DK120387 · NIDDK · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI LICHTERFELD, MATHIAS, YUKL, STEVEN A · 2019 to 2023
$4.1M
Phenotypic and mechanistic analysis of the in vivo HIV latent reservoir by single-cell technologiesR01AI147777 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROAN, NADIA R · 2019 to 2022
$3.8M
Investigating Mechanisms of HIV Persistence in the GutR01DK108349 · NIDDK · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI YUKL, STEVEN A · 2015 to 2019
$2.2M
NHLBI NIH HHS U01 HL146193NHLBI NIH HHS U01 HL146242NIAID NIH HHS P01 AI131374NIAID NIH HHS P01 AI169606NIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI127219NIAID NIH HHS R01 AI132128NIAID NIH HHS R01 AI147777NIAID NIH HHS U01 AI034989NIAID NIH HHS UM1 AI164559NIAID NIH HHS UM1 AI164567NIDDK NIH HHS P30 DK063720NIDDK NIH HHS R01 DK108349NIDDK NIH HHS R01 DK120387NIH HHS S10 OD018040
6 · The paper itself

Abstract

T cells residing in mucosal tissues play important roles in homeostasis and defense against microbial pathogens. The gut and female reproductive tract (FRT) are both tolerogenic environments, but they differ in the kinds of foreign Ags they need to tolerate. How these different environments influence the properties of their T cells is poorly understood, but important for understanding women's health. We recruited antiretroviral therapy-suppressed women living with HIV who donated, within one visit, blood and tissue samples from the ileum, colon, rectosigmoid, endometrium, endocervix, and ectocervix. With these samples, we conducted 36-parameter cytometry by time of flight phenotyping of T cells. Although gut and FRT T cells shared features discriminating them from their blood counterparts, they also harbored features distinguishing them from one another. These included increased proportions of CD69

Indexed as

CD8-Positive T-LymphocytesHIV InfectionsAnti-Retroviral AgentsFemaleGenitaliaHumansLymphocyte CountAnti-Retroviral Agents

Identifiers

PMID35296537
PMCPMC8976750
OpenAlexW4221005791

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.