Evidence map›Paper›PMID 35296465›Full record

ReviewBMJ global health2022

Waiting for the truth: is reluctance in accepting an early origin hypothesis for SARS-CoV-2 delaying our understanding of viral emergence?

Marta Canuti, Silvia Bianchi, Otto Kolbl, Sergei L Kosakovsky Pond, Sudhir Kumar, Maria Gori, Clara Fappani, Daniela Colzani, Elisa Borghi, Gianvincenzo Zuccotti and 3 more

Abstract readReview
In one paragraph

Review in BMJ global health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marta Canuti *Department of Health Sciences, Università degli Studi di Milano, Milan, Italy marta.canuti@gmail.com silvia.bianchi@unimi.it antonella.amendola@unimi.it.ORCID 0000-0002-9959-128X
Silvia Bianchi *Department of Health Sciences, Università degli Studi di Milano, Milan, Italy marta.canuti@gmail.com silvia.bianchi@unimi.it antonella.amendola@unimi.it.ORCID 0000-0002-1365-9408
Otto KolblFaculty of Arts, University of Lausanne, Lausanne, Switzerland.
Sergei L Kosakovsky PondDepartment of Biology, Temple University, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-4817-4029
Sudhir KumarDepartment of Biology, Temple University, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-9918-8212
Maria GoriDepartment of Health Sciences, Università degli Studi di Milano, Milan, Italy.ORCID 0000-0001-6478-2791
Clara FappaniDepartment of Health Sciences, Università degli Studi di Milano, Milan, Italy.ORCID 0000-0002-1573-5531
Daniela ColzaniDepartment of Health Sciences, Università degli Studi di Milano, Milan, Italy.ORCID 0000-0002-4079-1957
Elisa BorghiDepartment of Health Sciences, Università degli Studi di Milano, Milan, Italy.ORCID 0000-0002-1893-0455
Gianvincenzo ZuccottiDepartment of Pediatrics, Ospedale dei Bambini, Università degli Studi di Milano, Milan, Italy.ORCID 0000-0002-2795-9874
Mario C RaviglioneCentre for Multidisciplinary Research in Health Science, Università degli Studi di Milano, Milan, Italy.ORCID 0000-0002-9331-2067
Elisabetta TanziDepartment of Health Sciences, Università degli Studi di Milano, Milan, Italy.ORCID 0000-0002-4119-701X
Antonella AmendolaDepartment of Health Sciences, Università degli Studi di Milano, Milan, Italy marta.canuti@gmail.com silvia.bianchi@unimi.it antonella.amendola@unimi.it.ORCID 0000-0002-0499-8977

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two years after the start of the COVID-19 pandemic, key questions about the emergence of its aetiological agent (SARS-CoV-2) remain a matter of considerable debate. Identifying when SARS-CoV-2 began spreading among people is one of those questions. Although the current canonically accepted timeline hypothesises viral emergence in Wuhan, China, in November or December 2019, a growing body of diverse studies provides evidence that the virus may have been spreading worldwide weeks, or even months, prior to that time. However, the hypothesis of earlier SARS-CoV-2 circulation is often dismissed with prejudicial scepticism and experimental studies pointing to early origins are frequently and speculatively attributed to false-positive tests. In this paper, we critically review current evidence that SARS-CoV-2 had been circulating prior to December of 2019, and emphasise how, despite some scientific limitations, this hypothesis should no longer be ignored and considered sufficient to warrant further larger-scale studies to determine its veracity.

Indexed as

COVID-19SARS-CoV-2ChinaHumansPandemicsCOVID-19epidemiologypublic healthSARS

Identifiers

PMID35296465
PMCPMC8927931

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.