Evidence map›Paper›PMID 35296386›Full record

ArticleThe journal of sexual medicine2022

Lack of Evidence for a Relationship Between Salivary CRP and Women's Sexual Desire: An Investigation Across Clinical and Healthy Samples.

Kirstin Clephane, Julia I O'Loughlin, Tamara S Bodnar, M Claire Wilson, Jordan Tb Stariha, Amber N Craig, Joanne Weinberg, Lori A Brotto, Tierney K Lorenz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of sexual medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Kirstin ClephaneUniversity of Nebraska - Lincoln, Center for Brain, Biology and Behavior, Lincoln, NE, USA; University of Nebraska - Lincoln, Psychology Department, Lincoln, NE, USA.
Julia I O'LoughlinUniversity of British Columbia, Department of Educational and Counselling Psychology, and Special Education, Vancouver, British Columbia, CA, USA.
Tamara S BodnarUniversity of British Columbia, Department of Cellular and Physiological Sciences, Vancouver, British Columbia, CA, USA.
M Claire WilsonIndiana University, Department of Psychological and Brain Sciences, Bloomington, IN, USA.
Jordan Tb StarihaUniversity of British Columbia, Department of Obstetrics and Gynecology, Vancouver, British Columbia, CA, USA.
Amber N CraigMedical College of Wisconsin, Department of Psychiatry and Behavioral Medicine, Milwaukee, WI, USA.
Joanne WeinbergUniversity of British Columbia, Department of Cellular and Physiological Sciences, Vancouver, British Columbia, CA, USA.
Lori A BrottoUniversity of British Columbia, Department of Obstetrics and Gynecology, Vancouver, British Columbia, CA, USA; University of British Columbia, Faculty of Medicine, Vancouver, British Columbia, CA, USA.
Tierney K LorenzUniversity of Nebraska - Lincoln, Center for Brain, Biology and Behavior, Lincoln, NE, USA; University of Nebraska - Lincoln, Psychology Department, Lincoln, NE, USA. Electronic address: tierney.lorenz@unl.edu.
University of Nebraska–Lincoln · USIndiana University Bloomington · USMedical College of Wisconsin · US

Funding

Testing the Efficacy of Ibudilast to Attenuate Meth-seeking and Associated Synaptic Inflammation at the Synapse (TEAMS)P20GM130461 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI Rick A Bevins · 2019 to 2026
$20.6M
Alcohol and Stress: Interactive EffectsR37AA007789 · NIAAA · UNIVERSITY OF BRITISH COLUMBIA · PI WEINBERG, JOANNE · 2009 to 2018
$2.6M
Prenatal Alcohol and NeuroimmunityR01AA022460 · NIAAA · UNIVERSITY OF BRITISH COLUMBIA · PI BODNAR, TAMARA SONIA, RAINEKI, CHARLIS · 2013 to 2024
$2.3M
Immune Dysregulation in FASD: Programming of health and neurobehavioral outcomesU01AA026101 · NIAAA · UNIVERSITY OF BRITISH COLUMBIA · PI WEINBERG, JOANNE · 2017 to 2021
$788k
NIAAA NIH HHS R01 AA022460NIAAA NIH HHS R37 AA007789NIAAA NIH HHS U01 AA026101NIGMS NIH HHS P20 GM130461
6 · The paper itself

Abstract

backgroundInflammation has been linked to a variety of mental and physical health outcomes that disproportionately impact women, and which can impair sexual function; thus, there is reason to expect a link between inflammation and women's sexual functioning.

aimTo test the hypothesis that higher concentrations of C-reactive protein (CRP), a general biomarker of inflammation, would predict women's lower sexual desire.

methodAs 2 independent research teams, we conducted 3 separate studies (total n = 405) that assessed salivary CRP and various measurements of sexual desire in different women populations. OUTCOMES: Female Sexual Function Index, Sexual Desire Inventory-2, Decreased Sexual Desire Screener, and Sexual Interest and Desire Inventory.

resultsRegardless of the way sexual desire was measured (e.g., state vs trait; general desire vs. desire functioning) and the population sampled (i.e., healthy vs. clinically diagnosed with sexual dysfunction), all the studies revealed null results. CLINICAL IMPLICATIONS: While exploratory, the convergence of these null results across studies and researchers suggests that if there is an association between inflammation and women's sexual desire, it is likely very subtle. STRENGTHS & LIMITATIONS: Across 2 independent research teams, 3 unrelated studies, and various measurements of sexual desire, results were consistent. These points lend to the generalizability of the results. However, study designs were cross-sectional.

conclusionsFuture research may reveal (i) a non-linear threshold effect, such that inflammation does not begin to impact women's sexual desire until it is at a high level, (ii) inflammatory biomarkers other than CRP might be more sensitive in detecting associations between inflammation and desire, should they exist, or (iii) the mechanisms underlying sexual dysfunction may differ between sexes. Clephane K, et al. Lack of Evidence for a Relationship Between Salivary CRP and Women's Sexual Desire: An Investigation Across Clinical and Healthy Samples. J Sex Med 2022;19:745-760.

Indexed as

C-Reactive ProteinLibidoSexual Dysfunction, PhysiologicalFemaleHumansInflammationSalivaSurveys and QuestionnairesC-Reactive ProteinCRPDesireHSDDInflammationSexual DysfunctionWomen

Identifiers

PMID35296386
PMCPMC9064911
OpenAlexW4221058137

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.