Evidence map›Paper›PMID 35296197›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2022

Diversely substituted sulfamides for fragment-based drug discovery of carbonic anhydrase inhibitors: synthesis and inhibitory profile.

Tatiana Sharonova, Petr Zhmurov, Stanislav Kalinin, Alessio Nocentini, Andrea Angeli, Marta Ferraroni, Mikhail Korsakov, Claudiu T Supuran, Mikhail Krasavin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tatiana SharonovaInstitute of Chemistry, Saint Petersburg State University, Saint Petersburg, Russia.
Petr ZhmurovInstitute of Chemistry, Saint Petersburg State University, Saint Petersburg, Russia.
Stanislav KalininInstitute of Chemistry, Saint Petersburg State University, Saint Petersburg, Russia.
Alessio NocentiniNeurofarba Department, Universita Degli Studi di Firenze, Florence, Italy.ORCID 0000-0003-3342-702X
Andrea AngeliNeurofarba Department, Universita Degli Studi di Firenze, Florence, Italy.ORCID 0000-0002-1470-7192
Marta FerraroniNeurofarba Department, Universita Degli Studi di Firenze, Florence, Italy.
Mikhail KorsakovPharmaceutical Technology Transfer Center, Ushinsky Yaroslavl State Pedagogical University, Yaroslavl, Russia.
Claudiu T SupuranNeurofarba Department, Universita Degli Studi di Firenze, Florence, Italy.ORCID 0000-0003-4262-0323
Mikhail KrasavinInstitute of Chemistry, Saint Petersburg State University, Saint Petersburg, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of sulfamide fragments has been synthesised and investigated for human carbonic anhydrase inhibition. One of the fragments showing greater selectivity for cancer-related isoforms

Indexed as

Drug DiscoveryCarbonic Anhydrase InhibitorsCarbonic AnhydrasesDose-Response Relationship, DrugHumansIsoenzymesMolecular StructureStructure-Activity RelationshipSulfonamidesCarbonic Anhydrase InhibitorsCarbonic AnhydrasesIsoenzymesSulfonamidesCarbonic anhydraseco-operative fragment screeningsolubilitysulfamideszinc-binding groups

Identifiers

PMID35296197
PMCPMC8933014

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.