Evidence map›Paper›PMID 35296178›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2022

Astrocyte regulation of cerebral blood flow during hypoglycemia.

Amy R Nippert, Pei-Pei Chiang, Armani P Del Franco, Eric A Newman

Open access · greenAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  5. Review
  6. Article
  7. Astrocyte involvement in metabolic regulation and disease.Trends in endocrinology and metabolism: TEM · 2025
    Review
  8. Review
  9. Vascular Function and Ion Channels in Alzheimer's Disease.Microcirculation (New York, N.Y. : 1994) · 2024
    Review
  10. Neural and Glial Regulation of Angiogenesis in CNS in Ischemic Stroke.Bulletin of experimental biology and medicine · 2024
    Review
  11. Astrocyte Regulation of Cerebral Blood Flow in Health and Disease.Cold Spring Harbor perspectives in biology · 2024
    Review
  12. Acute severe hypoglycemia alters mouse brain microvascular proteome.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  13. CCL5 mediated astrocyte-T cell interaction disrupts blood-brain barrier in mice after hemorrhagic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  14. Unraveling the brain's response to hypoglycemia: Neurovascular coupling.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  15. Whisker-evoked neurovascular coupling is preserved during hypoglycemia in mouse cortical arterioles and capillaries.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  16. Review
  17. Review
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  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Amy R NippertDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Pei-Pei ChiangDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Armani P Del FrancoDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Eric A NewmanDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
University of Minnesota · US

Funding

Visual TestingP30EY011374 · NEI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI NEWMAN, ERIC A · 1996 to 2019
$8.8M
Astrocyte regulation of cerebral blood flow during hypoglycemiaR01NS126166 · NINDS · UNIVERSITY OF MINNESOTA · PI ERIC A NEWMAN · 2022 to 2026
$1.9M
Regulation of Capillary Blood Flow in the Retina in Health and in Diabetic RetinopathyR01EY026514 · NEI · UNIVERSITY OF MINNESOTA · PI NEWMAN, ERIC A · 2016 to 2020
$1.9M
Glial cell regulation of blood flow in capillariesR01EY026882 · NEI · UNIVERSITY OF MINNESOTA · PI NEWMAN, ERIC A · 2016 to 2020
$1.7M
Training Program in Translational Vision SciencesT32EY025187 · NEI · UNIVERSITY OF MINNESOTA · PI Glenn P Lobo, LINDA K. MCLOON · 2016 to 2026
$1.2M
Regulation of blood flow in the brains of diabetic miceF31DK116498 · NIDDK · UNIVERSITY OF MINNESOTA · PI NIPPERT, AMY · 2017 to 2020
$104k
NEI NIH HHS P30 EY011374NEI NIH HHS R01 EY026514NEI NIH HHS R01 EY026882NEI NIH HHS T32 EY025187NIDDK NIH HHS F31 DK116498NINDS NIH HHS R01 NS126166
6 · The paper itself

Abstract

Hypoglycemia triggers increases in cerebral blood flow (CBF), augmenting glucose supply to the brain. We have tested whether astrocytes, which can regulate vessel tone, contribute to this CBF increase. We hypothesized that hypoglycemia-induced adenosine signaling acts to increase astrocyte Ca

Indexed as

HypoglycemiaInsulinsAnimalsArteriolesAstrocytesCerebrovascular CirculationMiceVasodilator AgentsInsulinsVasodilator Agentsadenosineastrocytescalcium signalingcerebral blood flowHypoglycemiaIP3R2 KO

Identifiers

PMID35296178
PMCPMC9274859
OpenAlexW4220685907

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.