Evidence map›Paper›PMID 35296177›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2022

Mapping oxidative metabolism in the human brain with calibrated fMRI in health and disease.

J Jean Chen, Biranavan Uthayakumar, Fahmeed Hyder

Open access · greenAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  6. Review
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  8. Article
  9. In vivo neuropil density from anatomical MRI and machine learning.Cerebral cortex (New York, N.Y. : 1991) · 2024
    Article
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  12. Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  13. Review
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  15. Human brain functional MRS reveals interplay of metabolites implicated in neurotransmission and neuroenergetics.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

J Jean ChenMedical Biophysics, University of Toronto, Toronto, Canada.
Biranavan UthayakumarMedical Biophysics, University of Toronto, Toronto, Canada.
Fahmeed HyderMagnetic Resonance Research Center (MRRC), Yale University, New Haven, Connecticut, USA.
Sunnybrook Hospital · CAUniversity of Toronto · CAYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Energetics of Neuronal Populations by fMRIR01MH067528 · NIMH · YALE UNIVERSITY · PI HYDER, DEWAN SYED FAHMEED · 2002 to 2021
$5.9M
Understanding evoked and resting-state fMRI through multi scale imagingR01MH111424 · NIMH · YALE UNIVERSITY · PI CONSTABLE, R TODD, CRAIR, MICHAEL C. · 2016 to 2020
$5.2M
MRS validation of computational metabolic modeling of human brain function to determine energetic disruptions underlying fMRI-derived functional connectivity in degenerative or psychiatric disordersR01NS100106 · NINDS · YALE UNIVERSITY · PI HYDER, DEWAN SYED FAHMEED, ROTHMAN, DOUGLAS LYLE · 2017 to 2021
$959k
CIHR FDN 148398CIHR PJT 169688NCATS NIH HHS UL1 TR001863NIMH NIH HHS R01 MH067528NIMH NIH HHS R01 MH111424NINDS NIH HHS R01 NS100106
6 · The paper itself

Abstract

Conventional functional MRI (fMRI) with blood-oxygenation level dependent (BOLD) contrast is an important tool for mapping human brain activity non-invasively. Recent interest in quantitative fMRI has renewed the importance of oxidative neuroenergetics as reflected by cerebral metabolic rate of oxygen consumption (CMR

Indexed as

BrainMagnetic Resonance ImagingBrain MappingCerebrovascular CirculationHumansOxidative StressOxygenOxygen ConsumptionOxygencalibrated BOLDCalibrated fMRIdual calibrationgas calibrationgas-free calibrationglucose metabolismgradient-spin echohypercapnic calibrationhyperoxic calibrationlocal-field potentialmulti-unit activityneuroenergeticsneuronal BOLDoxidative metabolismvascular BOLD

Identifiers

PMID35296177
PMCPMC9207484
OpenAlexW4220824410

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.