Evidence map›Paper›PMID 35296132›Full record

ArticleInternational journal of surgical oncology2022

High CD44 Immunoexpression Correlates with Poor Overall Survival: Assessing the Role of Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma Patients from the High-Risk Population of Pakistan.

Yumna Adnan, S M Adnan Ali, Hasnain A Farooqui, Hammad A Kayani, Romana Idrees, M Sohail Awan

Open access · hybridAbstract read
In one paragraph

Article in International journal of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Modulation ofInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. [Cancer stem cells in oral squamous cell carcinoma. Literature review].Revista cientifica odontologica (Universidad Cientifica del Sur)
    Review
  13. Article
  14. Immunoexpression of CD44, p16 and VEGF in oral cancer.Journal of oral and maxillofacial pathology : JOMFP
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yumna AdnanOffice of Academia and Research in Surgery, Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.ORCID https://orcid.org/0000-0001-6656-6961
S M Adnan AliOffice of Academia and Research in Surgery, Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.ORCID https://orcid.org/0000-0002-1783-4437
Hasnain A FarooquiOffice of Academia and Research in Surgery, Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.ORCID https://orcid.org/0000-0002-4716-100X
Hammad A KayaniDepartment of Biosciences, Faculty of Life Sciences, Shaheed Zulfikar Ali Bhutto Institute of Science and Technology, Karachi, Pakistan.ORCID https://orcid.org/0000-0002-3258-0535
Romana IdreesSection of Histopathology, Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, Pakistan.ORCID https://orcid.org/0000-0001-6980-0231
M Sohail AwanSection of Otolaryngology, Head and Neck Surgery, Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.ORCID https://orcid.org/0000-0001-8323-7350
Aga Khan University Hospital · PKShaheed Zulfiqar Ali Bhutto Institute of Science and Technology · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral squamous cell carcinoma (OSCC) is a top-ranked cancer in the Pakistani population, and patient survival has remained unchanged at ∼50% for several decades. Recent advances have claimed that a subset of tumour cells, called cancer stem cells (CSCs), are responsible for tumour progression, treatment resistance, and metastasis, which leads to a poor prognosis. This study investigated the impact of CSC markers expression on overall survival (OS) and disease-free survival (DFS) of OSCC patients.

Indexed as

Hyaluronan ReceptorsMouth NeoplasmsAC133 AntigenBiomarkers, TumorFemaleHumansMaleNeoplastic Stem CellsPakistanRisk FactorsSquamous Cell Carcinoma of Head and NeckAC133 AntigenBiomarkers, TumorCD44 protein, humanHyaluronan Receptors

Identifiers

PMID35296132
PMCPMC8920653
OpenAlexW4220960606

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.