ArticleFrontiers in toxicology2020
Internal Threshold of Toxicological Concern (iTTC): Where We Are Today and What Is Possible in the Near Future.
Article in Frontiers in toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Toward internal threshold for toxicological concern: in vitro hepatocyte metabolism testing of 207 chemicals using cryopreserved suspended hepatocytes for physiologically based pharmacokinetic modeling.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- A framework for evaluating less-than-lifetime exposures: advancing toxicological risk assessment for drinking water quality.Archives of toxicology · 2025Review
- Derivation of human toxicokinetic parameters and internal threshold of toxicological concern for tenuazonic acid through a human intervention trial and hierarchical Bayesian population modeling.Journal of exposure science & environmental epidemiology · 2025Article
- Sensitivity Analysis of the Inputs for Bioactivity-Exposure Ratio Calculations in a NAM-Based Systemic Safety Toolbox.NAM journal · 2025Article
- Characterization of medical device constituents and development of duration-based non-cancer threshold of toxicological concern values.Frontiers in toxicology · 2025Article
- Letter to the editor regarding recent publication titled "Developing an internal threshold of toxicological concern (iTTC)" by Arnot et al. (2022).Journal of exposure science & environmental epidemiology · 2023Article
- Atlantic Salmon Gill Epithelial Cell Line (ASG-10) as a Suitable Model for Xenobiotic Biotransformation.Metabolites · 2023Article
- Practical application of the interim internal threshold of toxicological concern (iTTC): a case study based on clinical data.Archives of toxicology · 2023Article
- Developing an internal threshold of toxicological concern (iTTC).Journal of exposure science & environmental epidemiology · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Threshold of Toxicological Concern (TTC) is a risk assessment tool for evaluating low-level exposure to chemicals with limited toxicological data. A next step in the ongoing development of TTC is to extend this concept further so that it can be applied to internal exposures. This refinement of TTC based on plasma concentrations, referred to as internal TTC (iTTC), attempts to convert the chemical-specific external NOAELs (in mg/kg/day) in the TTC database to an estimated internal exposure. A multi-stakeholder collaboration formed, with the aim of establishing an iTTC suitable for human safety risk assessment. Here, we discuss the advances and future directions for the iTTC project, including: (1) results from the systematic literature search for metabolism and pharmacokinetic data for the 1,251 chemicals in the iTTC database; (2) selection of ~350 chemicals that will be included in the final iTTC; (3) an overview of the
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.