Evidence map›Paper›PMID 35296082›Full record

ReviewFrontiers in immunology2022

Regulatory T Cells in Autoimmune Vasculitis.

Ke Jin, Simon Parreau, Kenneth J Warrington, Matthew J Koster, Gerald J Berry, Jörg J Goronzy, Cornelia M Weyand

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 28 citations in OpenAlex.

  1. Enhancing Bone Healing with a Priming Stimulus.Life (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Immune checkpoints in autoimmune vasculitis.Best practice & research. Clinical rheumatology · 2024
    Review
  12. Article
  13. Review
  14. Article
  15. CD83 Regulates the Immune Responses in Inflammatory Disorders.International journal of molecular sciences · 2023
    Review
  16. Immunology of Giant Cell Arteritis.Circulation research · 2023
    Review
  17. Article
  18. Review
  19. Advances in the Treatment of Giant Cell Arteritis.Journal of clinical medicine · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ke JinDepartment of Medicine, Mayo College of Medicine and Science, Rochester, MN, United States.
Simon ParreauDepartment of Medicine, Mayo College of Medicine and Science, Rochester, MN, United States.
Kenneth J WarringtonDepartment of Medicine, Mayo College of Medicine and Science, Rochester, MN, United States.
Matthew J KosterDepartment of Medicine, Mayo College of Medicine and Science, Rochester, MN, United States.
Gerald J BerryDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, United States.
Jörg J GoronzyDepartment of Medicine, Mayo College of Medicine and Science, Rochester, MN, United States.
Cornelia M WeyandDepartment of Medicine, Mayo College of Medicine and Science, Rochester, MN, United States.
Mayo Clinic · USStanford University · US

Funding

The NOTCH Signaling Pathway in Large Vessel VasculitisR01HL117913 · NHLBI · STANFORD UNIVERSITY · PI WEYAND, CORNELIA M. · 2014 to 2025
$5.0M
Oligoclonal T Cell Expansion &Rheumatoid ArthritisR01AR042527 · NIAMS · STANFORD UNIVERSITY · PI WEYAND, CORNELIA M. · 1993 to 2022
$4.8M
Telomere Damage Responses and Immune AgingR01AI108906 · NIAID · STANFORD UNIVERSITY · PI WEYAND, CORNELIA M. · 2014 to 2024
$4.0M
T Cell Immunity in Giant Cell ArteritisR01HL142068 · NHLBI · STANFORD UNIVERSITY · PI Cornelia M. Weyand · 2018 to 2026
$3.3M
NHLBI NIH HHS R01 HL117913NHLBI NIH HHS R01 HL142068NIAID NIH HHS R01 AI108906NIAMS NIH HHS R01 AR042527
6 · The paper itself

Abstract

Blood vessels are indispensable for host survival and are protected from inappropriate inflammation by immune privilege. This protection is lost in patients with autoimmune vasculitides, a heterogeneous group of diseases causing damage to arteries, arterioles, and capillaries. Vasculitis leads to vascular wall destruction and/or luminal occlusion, resulting in hemorrhage and tissue ischemia. Failure in the quantity and quality of immunosuppressive regulatory T cells (Treg) has been implicated in the breakdown of the vascular immune privilege. Emerging data suggest that Treg deficiencies are disease-specific, affecting distinct pathways in distinct vasculitides. Mechanistic studies have identified faulty CD8

Indexed as

Giant Cell ArteritisGranulomatosis with PolyangiitisMucocutaneous Lymph Node SyndromePolyarteritis NodosaArteriesHumansInflammationT-Lymphocytes, Regulatoryautoimmune diseaseexosomesgiant cell arteritisintracellular vesiclesNOTCHT cellsTreg cellvasculitis

Identifiers

PMID35296082
PMCPMC8918523
OpenAlexW4214731629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.