Evidence map›Paper›PMID 35295979›Full record

ArticleJournal of oral microbiology2022

Lack of direct association between oral mucosal lesions and SARS-CoV- 2 in a cohort of patients hospitalised with COVID-19.

Gabriela Schwab, Michelle Palmieri, Rodrigo M Zerbinati, Dmitry J S Sarmento, Thais Reis, Karem L Ortega, Italo T Kano, Rafael A V Caixeta, Bengt Hasséus, Dipak Sapkota and 7 more

Open access · goldAbstract read
In one paragraph

Article in Journal of oral microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 4 countries.

Gabriela SchwabLaboratory of Virology (Lim-52-hc-fmusp), Institute of Tropical Medicine of São Paulo, School of Medicine, University of São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-3034-8254
Michelle PalmieriDepartment of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Rodrigo M ZerbinatiLaboratory of Virology (Lim-52-hc-fmusp), Institute of Tropical Medicine of São Paulo, School of Medicine, University of São Paulo, São Paulo, Brazil.
Dmitry J S SarmentoDepartment of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-7972-9141
Thais ReisDepartment of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Karem L OrtegaDepartment of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Italo T KanoDepartment of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Rafael A V CaixetaDepartment of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Bengt HasséusDepartment of Oral Medicine and Pathology, Institute of Odontology, University of Gothenburg, Gothenburg, Sweden.ORCID https://orcid.org/0000-0003-3088-1550
Dipak SapkotaInstitute of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Roger JungesInstitute of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Simone GiannecchiniDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
André L F CostaPostgraduate Program in Dentistry, Cruzeiro Do Sul University, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-4856-5417
Sumatra M C P JalesDivision of Dentistry, Hospital Das Clínicas da Faculdade de Medicina da Universidade de São Paulo - Hcfmusp, School of Medicine, University of São Paulo, São Paulo, Brazil.
José A L LindosoInstitute of Infectious Diseases Emilio Ribas, São Paulo, Brazil.
Camila Barros GalloDepartment of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Paulo H Braz-SilvaLaboratory of Virology (Lim-52-hc-fmusp), Institute of Tropical Medicine of São Paulo, School of Medicine, University of São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-1842-9521
Universidade de São Paulo · BRUniversity of Oslo · NOHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRUniversidade Cruzeiro do Sul · BRUniversidade Estadual da Paraíba · BRUniversity of Florence · ITUniversity of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: COVID-19 is a disease affecting various human organs and systems, in which the virus seeks to interact with angiotensin-converting enzyme 2 receptors. These receptors are present in the oral cavity, but the direct relationship between such an interaction and possible oral manifestations of COVID-19 is still unclear. Aim: The present study evaluated oral manifestations in a cohort of COVID-19 patients during the period of hospitalisation. Methods: In total, 154 patients presenting moderate-to-severe forms of COVID-19 had their oral mucosa examined twice a week until the final outcome, either discharge or death. The oral alterations observed in the patients were grouped into Group 1 (pre-existing conditions and opportunistic oral lesions) and Group 2 (oral mucosal changes related to hospitalization). Results: Oral lesions found in the patients of Group 1 are not suggestive of SARS-CoV-2 infection as they are mainly caused by opportunistic infections. On the other hand, oral alterations found in the patients of Group 2 were statistically ( Conclusion: It is unlikely that ulcerative lesions in the oral cavity are a direct manifestation of SARS-CoV-2 or a marker of COVID-19 progression.

Indexed as

COVID-19HSV-1opportunistic infectionsOral ulcerSARS-CoV-2

Identifiers

PMID35295979
PMCPMC8920376
OpenAlexW4221075192

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.