Evidence map›Paper›PMID 35295834›Full record

ArticleFrontiers in neurology2022

Regulatory B Cells Are Decreased and Functionally Impaired in Myasthenia Gravis Patients.

Ye Lin, Ting Chang, Jiaji Lin, Chenjing Sun, Chao Wei, Jiao Zhao, Rui Liu, Kun Yang, Zhuyi Li

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. The role and mechanism of IL‑35 in myasthenia gravis (Review).International journal of molecular medicine · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. The imbalance between Bregs, Tfh, and Tregs in patients with anti-N-methyl-D-aspartate receptor encephalitis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Article
  9. Inflammation and autoimmune myasthenia gravis.Frontiers in immunology · 2023
    Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ye LinDepartment of Neurology, Tangdu Hospital, Air Force Medical University, Xi'an, China.
Ting ChangDepartment of Neurology, Tangdu Hospital, Air Force Medical University, Xi'an, China.
Jiaji LinDepartment of Neurology, Tangdu Hospital, Air Force Medical University, Xi'an, China.
Chenjing SunDepartment of Neurology, Chinese PLA General Hospital, Beijing, China.
Chao WeiDepartment of Neurology, Chinese PLA General Hospital, Beijing, China.
Jiao ZhaoDepartment of Neurology, Chinese PLA General Hospital, Beijing, China.
Rui LiuDepartment of Rehabilitation, Tangdu Hospital, Air Force Medical University, Xi'an, China.
Kun YangDepartment of Immunology, Basic Medicine School, Air Force Medical University, Xi'an, China.
Zhuyi LiDepartment of Neurology, Tangdu Hospital, Air Force Medical University, Xi'an, China.
Air Force Medical University · CNChinese PLA General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myasthenia gravis (MG) is an autoimmune disease mediated by B cells secreting autoantibodies. Regulatory B (Breg) cells confirmed to have an immunosuppressive function play an important role in many autoimmune diseases. However, what about the changes in Breg cells in the thymus and peripheral blood of MG patients? The changes in the proportion of Breg cells in the peripheral blood of 41 MG patients without any drug treatment and 30 healthy controls were detected by flow cytometry. We found that the proportions of CD19

Indexed as

anti-acetylcholine receptor antibodyautoimmune diseaseIL-10myasthenia gravisregulatory B cellSTAT3

Identifiers

PMID35295834
PMCPMC8918563
OpenAlexW4225659791

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.