Evidence map›Paper›PMID 35295756›Full record

ArticleFrontiers in cellular and infection microbiology2022

Sleep Disordered Breathing and Recurrent Tonsillitis Are Associated With Polymicrobial Bacterial Biofilm Infections Suggesting a Role for Anti-Biofilm Therapies.

Tulia Mateus, Elke J Seppanen, Camilla de Gier, Sharon Clark, Harvey Coates, Shyan Vijayasekaran, Karen Prosser, Selma P Wiertsema, Angela Fuery, Lea-Ann S Kirkham and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Tulia MateusSchool of Medicine, University of Western Australia, Perth, WA, Australia.
Elke J SeppanenWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, WA, Australia.
Camilla de GierSchool of Medicine, University of Western Australia, Perth, WA, Australia.
Sharon ClarkSchool of Medicine, University of Western Australia, Perth, WA, Australia.
Harvey CoatesSchool of Medicine, University of Western Australia, Perth, WA, Australia.
Shyan VijayasekaranSchool of Medicine, University of Western Australia, Perth, WA, Australia.
Karen ProsserPerth Children's Hospital, Perth, WA, Australia.
Selma P WiertsemaSchool of Medicine, University of Western Australia, Perth, WA, Australia.
Angela FueryWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, WA, Australia.
Lea-Ann S KirkhamWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, WA, Australia.
Peter C RichmondSchool of Medicine, University of Western Australia, Perth, WA, Australia.
Ruth B ThorntonWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, WA, Australia.
The Kids Research Institute Australia · AUPrincess Margaret Hospital for Children · AUUniversity of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The underlying pathogenesis of pediatric obstructive sleep disordered breathing (SDB) and recurrent tonsillitis (RT) are poorly understood but need to be elucidated to develop less invasive treatment and prevention strategies. Methods: Children aged between 1- and 16-years undergoing adenoidectomy, tonsillectomy or adenotonsillectomy for SDB (n=40), RT alone (n=18), or both SDB and RT (SDB+RT) (n=17) were recruited with age-matched healthy controls (n=33). Total bacterial load and species-specific densities of nontypeable Results: The 5 bacterial species were detected in naso- and oro- pharyngeal samples from all children. These species were frequently detected in adenotonsillar tissue (except Conclusions: Antimicrobials, particularly anti-biofilm therapies, may be a strategy for managing children with SDB.

Indexed as

Sleep Apnea SyndromesTonsillitisBiofilmsChildHumansRNA, Ribosomal, 16SStaphylococcus aureusRNA, Ribosomal, 16Sbacteriabiofilmsnontypeable Haemophilus influenzaepediatric sleep disordered breathingrecurrent tonsillitisStreptococcus pneumoniaeStreptococcus pyogenes

Identifiers

PMID35295756
PMCPMC8918577
OpenAlexW4214571021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.