Evidence map›Paper›PMID 35295746›Full record

ArticleeNeurologicalSci2022

Thymoma-associated anti-LGI1 encephalitis and myasthenia gravis: A unique combination with autoantibodies.

Akane Satake, Takamura Nagasaka, Takafumi Kurita, Hiroaki Murata, Takanori Hata, Hiroyuki Shinmura, Hirochika Matsubara, Kazumasa Shindo, Yoshihisa Takiyama

Open access · goldAbstract readCase Reports
In one paragraph

Article in eNeurologicalSci, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Akane SatakeDepartment of Neurology, Faculty of Medicine, University of Yamanashi, Japan.
Takamura NagasakaDepartment of Neurology, Faculty of Medicine, University of Yamanashi, Japan.
Takafumi KuritaDepartment of Neurology, Faculty of Medicine, University of Yamanashi, Japan.
Hiroaki MurataDepartment of Neurology, Faculty of Medicine, University of Yamanashi, Japan.
Takanori HataDepartment of Neurology, Faculty of Medicine, University of Yamanashi, Japan.
Hiroyuki ShinmuraDepartment of Neurology, Kofu Kyoritsu Hospital, Yamanashi, Japan.
Hirochika MatsubaraDepartment of Thoracic Surgery, Faculty of Medicine, University of Yamanashi, Japan.
Kazumasa ShindoDepartment of Neurology, Faculty of Medicine, University of Yamanashi, Japan.
Yoshihisa TakiyamaDepartment of Neurology, Faculty of Medicine, University of Yamanashi, Japan.
University of Yamanashi · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a 77-year-old woman with a thymoma, anti-LGI1antibody associated encephalitis (LGI1 encephalitis), and MG accompanied by positive anti-acetylcholine receptor antibodies (AchR Ab) and anti-titin antibodies (titin Ab). She was treated with thymomectomy followed by immunosuppressive therapy, which resulted in immediate amelioration of motor weakness and gradual improvement of cognitive impairment over the next two years. LGI1 Ab were positive at two months after thymomectomy, followed by negative conversion demonstrated on 1 year examination. The AchR Ab level had gradually decreased but titin Ab was positive on re-examination after two years, although the cognition and motor impairment symptoms had been alleviated. In patients with suspected autoimmune encephalitis, the detection of several autoantibodies including LGI1 and thymomas provides useful information for making an accurate diagnosis.

Indexed as

Anti-LGI1 encephalitisMyasthenia gravisMyokymiaThymoma

Identifiers

PMID35295746
PMCPMC8919234
OpenAlexW4221021144

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.