ReviewFrontiers in pharmacology2021
Antimicrobial Diterpenes: Recent Development From Natural Sources.
Review in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Essential Oils of Lamiaceae Species as Promising Sources of Antimycobacterial Agents: Current Insights, Challenges, and Future Perspectives.Molecules (Basel, Switzerland) · 2026Review
- Integrated Chemical Profiling and Biological Assessment ofAntibiotics (Basel, Switzerland) · 2026Article
- Antibacterial Activity of Ent-Clerodane-Type Diterpenoids and Flavonoids From the Roots of Croton pseudopulchellus Pax (Euphorbiaceae).Chemistry & biodiversity · 2026Article
- Plant-Derived Terpenes as Emerging Therapeutics Against Schistosomiasis.International journal of molecular sciences · 2026Review
- Article
- Antifungal activity of oily core PEGylated PLGA nanocapsules loaded with Penicillium oxalicum fungal extract: in vitro, in vivo, and in silico study.Microbial cell factories · 2026Article
- Uncovering the gastroprotective properties of araucaria brown propolis and its active compound, abietic acid.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Pharmacological evaluation of mangrove plant Rhizophora mucronata (Lam.) grown in the coastal area of Sundarbans.PloS one · 2026Article
- The Challenging Complete and DetailedACS omega · 2025Article
- Bioactive Plant-Derived Compounds as Novel Perspectives in Oral Cancer Alternative Therapy.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Isolation, structural elucidation, and integrated biological and computational evaluation of antidiabetic labdane diterpenes fromRSC advances · 2025Article
- Phytochemical Analysis and Biological Activities ofPlants (Basel, Switzerland) · 2025Article
- Biological Activities ofPharmaceuticals (Basel, Switzerland) · 2025Review
- Diterpenoids of Marine Organisms: Isolation, Structures, and Bioactivities.Marine drugs · 2025Review
- Development and Evaluation of the Antibacterial Properties of an Experimental Herbal Gel Against Cariogenic Bacteria.Clinical and experimental dental research · 2025Article
- Rosthornin B alleviates inflammatory diseases via directly targeting NLRP3.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Exploring the therapeutic potential of diterpenes in gastric cancer: Mechanisms, efficacy, and clinical prospects.Biomolecules & biomedicine · 2024Review
- Characterization of Tomato Seed Endophytic Bacteria as Growth Promoters and Potential Biocontrol Agents.The plant pathology journal · 2024Article
- Three NewMolecules (Basel, Switzerland) · 2024Article
- A Review of Sponge-Derived Diterpenes: 2009-2022.Marine drugs · 2024Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial resistance has been posing an alarming threat to the treatment of infectious diseases over the years. Ineffectiveness of the currently available synthetic and semisynthetic antibiotics has led the researchers to discover new molecules with potent antimicrobial activities. To overcome the emerging antimicrobial resistance, new antimicrobial compounds from natural sources might be appropriate. Secondary metabolites from natural sources could be prospective candidates in the development of new antimicrobial agents with high efficacy and less side effects. Among the natural secondary metabolites, diterpenoids are of crucial importance because of their broad spectrum of antimicrobial activity, which has put it in the center of research interest in recent years. The present work is aimed at reviewing recent literature regarding different classes of natural diterpenes and diterpenoids with significant antibacterial, antifungal, antiviral, and antiprotozoal activities along with their reported structure-activity relationships. This review has been carried out with a focus on relevant literature published in the last 5 years following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A total of 229 diterpenoids from various sources like plants, marine species, and fungi are summarized in this systematic review, including their chemical structures, classification, and significant antimicrobial activities together with their reported mechanism of action and structure-activity relationships. The outcomes herein would provide researchers with new insights to find new credible leads and to work on their synthetic and semisynthetic derivatives to develop new antimicrobial agents.
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Registered trials
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